R24GM141526

NMR User Program at NMRFAM - Project Summary

The National Magnetic Resonance Facility at Madison (NMRFAM) provides timely and reliable access to mature NMR technology for application to a wide array of biomedical research questions. NMRFAM has staff with decades of experience in facility operation and maintenance, a dozen high-field NMR spectrometers equipped with state-of-the-art probe technology, and facility infrastructure (ample space, uninterrupted power systems, environmental control, helium recovery) second to none. NMRFAM has been at the forefront of standardization, data stewardship through FAIR (Findable, Accessible, Interoperable, and Reusable) data principles, and dissemination of best practices to the community.

Support through the NIGMS R24 program of NMRFAM, through the R24 mechanism at NIGMS, would support broad access to this exceptional resource in Madison to leverage economies of scale. This includes stable and efficient operation that maximizes data quality and minimizes instrument downtime, facilitating many types of experiments that scientists are not able to perform at their home institutions. Furthermore, the proposed Next Generation User Program improves the rigor and reproducibility of NMR data collection through instrument quality control, standard operating procedures, new sample standards for microcrystalline proteins and nucleic acids, membrane proteins and fibrils. This also includes the development of approaches for dynamics and function, as well as structure.

NMRFAM staff provide an exceptional level of service tailored to the needs of individual users and projects, serving arguably the broadest user base of any NMR facility in the US. NMRFAM actively seeks to support diverse users through outreach and user training opportunities such as workshops, video tutorials, and protocols. These resources aim to teach users how to understand and analyze their NMR data. NMRFAM has a goal of providing users more than spectra, and the facility provides staff support and automation tools to return deliverables, i.e., scientific knowledge, not only data.

The NMRFAM mission lowers barriers to NMR and maximizes the impact of the facility when users can successfully apply the NMR data to answer their biological question of interest. NMRFAM has built a reputation as a top-level facility for external users, and this project will maintain affordable access to NMRFAM. NMRFAM staff will regularly evaluate performance criteria and consult with the external advisory committee and facility users so that the facility continues to remain at the cutting edge and meet the needs of its user base.

University Of Wisconsin System

THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES (NIGMS) SUPPORTS BASIC RESEARCH THAT INCREASES OUR UNDERSTANDING OF BIOLOGICAL PROCESSES AND LAYS THE FOUNDATION FOR ADVANCES IN DISEASE DIAGNOSIS, TREATMENT, AND PREVENTION. NIGMS ALSO SUPPORTS RESEARCH IN SPECIFIC CLINICAL AREAS THAT AFFECT MULTIPLE ORGAN SYSTEMS: ANESTHESIOLOGY AND PERI-OPERATIVE PAIN, CLINICAL PHARMACOLOGY ?COMMON TO MULTIPLE DRUGS AND TREATMENTS, AND INJURY, CRITICAL ILLNESS, SEPSIS, AND WOUND HEALING.? NIGMS-FUNDED SCIENTISTS INVESTIGATE HOW LIVING SYSTEMS WORK AT A RANGE OF LEVELSFROM MOLECULES AND CELLS TO TISSUES AND ORGANSIN RESEARCH ORGANISMS, HUMANS, AND POPULATIONS. ADDITIONALLY, TO ENSURE THE VITALITY AND CONTINUED PRODUCTIVITY OF THE RESEARCH ENTERPRISE, NIGMS PROVIDES LEADERSHIP IN SUPPORTING THE TRAINING OF THE NEXT GENERATION OF SCIENTISTS, ENHANCING THE DIVERSITY OF THE SCIENTIFIC WORKFORCE, AND DEVELOPING RESEARCH CAPACITY THROUGHOUT THE COUNTRY.

93.859 - Biomedical Research and Research Training

National Institute of General Medical Sciences (NIGMS) [HHS - NIH]

Madison, Wisconsin 53715 United States

Single Zip Code

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) (PA-20-272)

Amendment Since initial award the total obligations have increased 460% from $966,566 to $5,410,101.