R21TW011944
Project Grant
Overview
Grant Description
Using Community Health Centers to Mitigate the Impact of Snakebite Envenoming in Low Resource Areas - Abstract
Globally, more than 90% of all snakebite envenomation (SBE) occur in low resource settings. This neglected tropical disease affects 2.7 million people, with 81,000-138,000 deaths, and approximately 400,000 permanent disabilities annually. Antivenom is a safe, efficacious, time-dependent, and evidence-based treatment, but the availability and timely access to this standard of care is inadequate.
It is critical to engage local communities to improve timely access in remote, low resource areas where most SBE morbidity occurs. This proposal will develop and evaluate an innovative multi-modal intervention to improve SBE care, including decentralized antivenom distribution among the existing Community Healthcare Center (CHC) network in the Brazilian Amazon.
This novel intervention will integrate (a) advanced geospatial artificial intelligence to create decentralized antivenom distribution models using existing CHCs that optimizes population coverage and time to reach care, (b) a cost-effectiveness evaluation model developed with key stakeholders, and (c) a culturally relevant SBE care package containing education, treatment guidelines, training on antivenom delivery, and interfacity care coordination.
Using the Consolidated Framework for Implementation Research, we will conduct a formative evaluation of this multi-modal intervention and prepare an implementation strategy for the Brazilian Amazon, as well as prepare to scale up to other low resource locations. Consequently, we will have a standardized approach to use advanced analytics to optimize healthcare delivery in low resource settings that can be used in other countries and with other healthcare interventions.
Globally, more than 90% of all snakebite envenomation (SBE) occur in low resource settings. This neglected tropical disease affects 2.7 million people, with 81,000-138,000 deaths, and approximately 400,000 permanent disabilities annually. Antivenom is a safe, efficacious, time-dependent, and evidence-based treatment, but the availability and timely access to this standard of care is inadequate.
It is critical to engage local communities to improve timely access in remote, low resource areas where most SBE morbidity occurs. This proposal will develop and evaluate an innovative multi-modal intervention to improve SBE care, including decentralized antivenom distribution among the existing Community Healthcare Center (CHC) network in the Brazilian Amazon.
This novel intervention will integrate (a) advanced geospatial artificial intelligence to create decentralized antivenom distribution models using existing CHCs that optimizes population coverage and time to reach care, (b) a cost-effectiveness evaluation model developed with key stakeholders, and (c) a culturally relevant SBE care package containing education, treatment guidelines, training on antivenom delivery, and interfacity care coordination.
Using the Consolidated Framework for Implementation Research, we will conduct a formative evaluation of this multi-modal intervention and prepare an implementation strategy for the Brazilian Amazon, as well as prepare to scale up to other low resource locations. Consequently, we will have a standardized approach to use advanced analytics to optimize healthcare delivery in low resource settings that can be used in other countries and with other healthcare interventions.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Durham,
North Carolina
27705
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the End Date has been extended from 03/31/23 to 03/31/24 and the total obligations have increased 128% from $234,520 to $534,290.
Duke University was awarded
Enhancing SBE Care via CHCs in Low-Resource Areas
Project Grant R21TW011944
worth $534,290
from Fogarty International Center in July 2021 with work to be completed primarily in Durham North Carolina United States.
The grant
has a duration of 2 years 8 months and
was awarded through assistance program 93.989 International Research and Research Training.
The Project Grant was awarded through grant opportunity Dissemination and Implementation Research in Health (R21 Clinical Trial Optional).
Status
(Complete)
Last Modified 9/5/24
Period of Performance
7/12/21
Start Date
3/31/24
End Date
Funding Split
$534.3K
Federal Obligation
$0.0
Non-Federal Obligation
$534.3K
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R21TW011944
Transaction History
Modifications to R21TW011944
Additional Detail
Award ID FAIN
R21TW011944
SAI Number
R21TW011944-4289467444
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NF00 NIH FOGARTY INTERNATIONAL CENTER
Funding Office
75NF00 NIH FOGARTY INTERNATIONAL CENTER
Awardee UEI
TP7EK8DZV6N5
Awardee CAGE
4B478
Performance District
NC-04
Senators
Thom Tillis
Ted Budd
Ted Budd
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| John E. Fogarty International Center, National Institutes of Health, Health and Human Services (075-0819) | Health research and training | Grants, subsidies, and contributions (41.0) | $299,770 | 100% |
Modified: 9/5/24