R21MH134114
Project Grant
Overview
Grant Description
Epigenetic biomarkers of postpartum psychosis - Abstract
Reproductive mood episodes, such as postpartum depression, premenstrual dysphoric disorder, and postpartum psychosis, are mood episodes triggered by reproductive hormonal changes in women.
We have previously identified two epigenetic biomarkers of postpartum depression at the TTC9B and HP1BP3 genes that are approximately 80% accurate in predicting which women will be depressed in the postpartum time-period.
We have recently shown that these biomarkers are also associated with women that have premenstrual dysphoric disorder when blood is sampled in the luteal phase of the menstrual cycle, indicating that they may be more general biomarkers of brain sensitivity to reproductive hormone fluctuations.
This proposal will take advantage of a unique sample of blood specimens collected in the Netherlands from women with postpartum psychosis and will determine if our epigenetic biomarkers are also associated with postpartum psychosis.
We will also conduct a genome-wide microarray analysis in order to identify epigenetic biomarkers that are specific to postpartum psychosis.
Postpartum psychosis is a serious psychiatric illness with acute onset in the immediate postpartum time period.
Postpartum psychosis almost always requires psychiatric hospitalization and carries with it an elevated risk of suicide and infanticide.
Identification of blood-based biomarkers that are predictive of an increased risk for postpartum psychosis would allow for preventative measures which may eliminate a psychiatric emergency and prevent hospitalization during the critical postpartum time period.
Reproductive mood episodes, such as postpartum depression, premenstrual dysphoric disorder, and postpartum psychosis, are mood episodes triggered by reproductive hormonal changes in women.
We have previously identified two epigenetic biomarkers of postpartum depression at the TTC9B and HP1BP3 genes that are approximately 80% accurate in predicting which women will be depressed in the postpartum time-period.
We have recently shown that these biomarkers are also associated with women that have premenstrual dysphoric disorder when blood is sampled in the luteal phase of the menstrual cycle, indicating that they may be more general biomarkers of brain sensitivity to reproductive hormone fluctuations.
This proposal will take advantage of a unique sample of blood specimens collected in the Netherlands from women with postpartum psychosis and will determine if our epigenetic biomarkers are also associated with postpartum psychosis.
We will also conduct a genome-wide microarray analysis in order to identify epigenetic biomarkers that are specific to postpartum psychosis.
Postpartum psychosis is a serious psychiatric illness with acute onset in the immediate postpartum time period.
Postpartum psychosis almost always requires psychiatric hospitalization and carries with it an elevated risk of suicide and infanticide.
Identification of blood-based biomarkers that are predictive of an increased risk for postpartum psychosis would allow for preventative measures which may eliminate a psychiatric emergency and prevent hospitalization during the critical postpartum time period.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Charlottesville,
Virginia
229034833
United States
Geographic Scope
Single Zip Code
Rector & Visitors Of The University Of Virginia was awarded
Project Grant R21MH134114
worth $451,138
from the National Institute of Mental Health in August 2023 with work to be completed primarily in Charlottesville Virginia United States.
The grant
has a duration of 2 years and
was awarded through assistance program 93.242 Mental Health Research Grants.
The Project Grant was awarded through grant opportunity NIMH Exploratory/Developmental Research Grant (R21 Clinical Trial Not Allowed).
Status
(Complete)
Last Modified 12/21/23
Period of Performance
8/2/23
Start Date
8/1/25
End Date
Funding Split
$451.1K
Federal Obligation
$0.0
Non-Federal Obligation
$451.1K
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R21MH134114
Transaction History
Modifications to R21MH134114
Additional Detail
Award ID FAIN
R21MH134114
SAI Number
R21MH134114-286974708
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75N700 NIH NATIONAL INSTITUTE OF MENTAL HEALTH
Funding Office
75N700 NIH NATIONAL INSTITUTE OF MENTAL HEALTH
Awardee UEI
JJG6HU8PA4S5
Awardee CAGE
9B982
Performance District
VA-05
Senators
Mark Warner
Timothy Kaine
Timothy Kaine
Budget Funding
Federal Account | Budget Subfunction | Object Class | Total | Percentage |
---|---|---|---|---|
National Institute of Mental Health, National Institutes of Health, Health and Human Services (075-0892) | Health research and training | Grants, subsidies, and contributions (41.0) | $451,138 | 100% |
Modified: 12/21/23