R13AR085494

2025 Cartilage Biology and Pathology Gordon Research Conference and Gordon Research Seminar - Abstract

Cartilage supports skeletal development from embryos to adulthood.

It also serves as an essential skeletal component of a functional adult skeletal system.

Cartilage malformation or degenerative cartilage disease, most notably osteoarthritis, significantly affects the lifespan, quality of life, and productivity of a large proportion of the population world-wide.

As life expectancy rises, the personal and economic consequences of these conditions are expected to increase.

Since there is an unmet need for treatment and prevention of cartilage diseases, linking expertise from different research disciplines and career stages is of utmost importance.

This is a request to support the 2025 Gordon Research Conference (GRC) and associated, preceding Gordon Research Seminar (GRS) on cartilage biology and pathology, which will be held at the Sheraton Fairplex Hotel & Conference Center, Pomona, California, March 22-28, 2025.

The GRC will cover broad basic and translational research topics with the theme of “Genes, Molecules and Mechanics in Musculoskeletal Tissue Development and Disease”.

The overall goal is to foster collaborations that will ultimately lead to novel treatments.

The 2025 conference is the 11th in the series and owes its success to three major principles.

First, it is the only conference that brings together basic science researchers, clinician-scientists, and biomedical engineers to cover a broad spectrum of cartilage biology, pathology, and other disciplines relevant to cartilage research.

Second, the program emphasizes unpublished cutting-edge findings, state-of-the-art technologies, and open discussions.

Third, it is open to researchers at all career stages and encourages mentoring, networking, and collaboration among young and senior investigators.

The 2025 Cartilage GRC will highlight recent advances and challenges in understanding cartilage biology and disease.

The program alternates between formal presentations, poster sessions, and informal discussions.

Attendance is limited to 200 participants to promote collegial interactions.

Established scientists and talented new investigators will report and discuss their most recent exciting findings and provide insights into challenges towards understanding cartilage biology, disease, and therapeutic approaches.

Interdisciplinary collaborations are fostered through a broad base of session topics in an intimate environment, promoting discussion among those in different areas of research and career stage.

For example, bioengineers and clinicians will benefit from learning about how tissues develop so that those principles can be applied to engineering and regenerative treatment strategies.

The preceding GRS, run by and for trainees, provides a forum for trainees to present and discuss their work among their peers, building confidence for discussion and networking.

In addition, the GRS includes a mentoring panel, where trainees are provided with information on career paths, grant writing, and other career topics.

We expect the 2025 GRC/GRS on cartilage biology and pathology to empower researchers across disciplines to make significant progress toward understanding cartilage biology and improving human health.

Gordon Research Conferences

THE NATIONAL INSTITUTE OF AND MUSCULOSKELETAL AND SKIN DISEASES (NIAMS) MISSION IS TO SUPPORT RESEARCH INTO THE CAUSES, TREATMENT, AND PREVENTION OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES, TRAINING OF BASIC AND CLINICAL SCIENTISTS TO CARRY OUT THIS RESEARCH, AND DISSEMINATION OF INFORMATION ON RESEARCH PROGRESS IN THESE DISEASES. THE EXTRAMURAL PROGRAM PROMOTES AND SUPPORTS BASIC, TRANSLATIONAL, AND CLINICAL STUDIES OF SYSTEMIC RHEUMATIC AND AUTOIMMUNE DISEASES, SKIN BIOLOGY AND DISEASES, BONE BIOLOGY AND DISEASES, MUSCLE BIOLOGY AND DISEASES, AND JOINT BIOLOGY AND DISEASES AND ORTHOPAEDICS. NIAMS SYSTEMIC RHEUMATIC AND AUTOIMMUNE DISEASES PROGRAMS ADDRESS BASIC, TRANSLATIONAL, AND CLINICAL RESEARCH, INCLUDING CLINICAL TRIALS AND OBSERVATIONAL AND MECHANISTIC STUDIES, FOCUSED ON IMMUNE-MEDIATED ARTHRITIS AND AUTOIMMUNE-RELATED ACUTE AND CHRONIC DISORDERS IN ADULTS AND CHILDREN. NIAMS SKIN BIOLOGY AND DISEASES PROGRAMS SUPPORT BASIC, TRANSLATIONAL, AND CLINICAL RESEARCH IN SKIN, INCLUDING BOTH COMMON AND RARE SKIN DISEASES. THESE PROGRAMS INCLUDE INVESTIGATIONS OF THE BASIC MOLECULAR, CELLULAR, AND DEVELOPMENTAL BIOLOGY OF SKIN, AS WELL AS STUDIES OF SKIN AS AN IMMUNE, SENSORY, ENDOCRINE, AND METABOLIC ORGAN. NIAMS BONE BIOLOGY AND DISEASES PROGRAMS SUPPORT RESEARCH ON THE CONTROL OF BONE FORMATION, RESORPTION, AND MINERALIZATION AS WELL AS THE EFFECTS OF SIGNALING MOLECULES ON BONE CELLS. THEY SUPPORT CLINICAL STUDIES OF INTERVENTIONS TO PREVENT FRACTURES ASSOCIATED WITH OSTEOPOROSIS AND RESEARCH INTO LESS COMMON BONE DISEASES. NIAMS MUSCLE BIOLOGY AND DISEASES PROGRAMS ENCOURAGE RESEARCH ON MUSCLE DEVELOPMENTAL BIOLOGY, GROWTH, MAINTENANCE, AND HYPERTROPHY, PHYSIOLOGY OF CONTRACTION, STRUCTURAL BIOLOGY OF THE CONTRACTILE APPARATUS, DISEASE MECHANISMS, BIOMARKERS AND OUTCOME MEASURES, AND DEVELOPMENT AND CLINICAL TESTING OF THERAPIES FOR CONDITIONS INCLUDING THE MUSCULAR DYSTROPHIES. NIAMS JOINT BIOLOGY, DISEASES, AND ORTHOPAEDICS PROGRAMS SUPPORT A BROAD SPECTRUM OF RESEARCH CENTERED ON THE INTERPLAY AMONG THE BODY'S MUSCLES, BONES, AND CONNECTIVE TISSUES. THEY ENCOURAGE TISSUE ENGINEERING AND REGENERATIVE MEDICINE RESEARCH, MOLECULAR BIOLOGY, IMAGING, AND CLINICAL RESEARCH, AND THE TREATMENT AND PREVENTION OF ORTHOPAEDIC CONDITIONS. NIAMS PARTICIPATES IN THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS. THE SBIR PROGRAM IS INTENDED TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE STTR PROGRAM IS INTENDED TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.846 - Arthritis, Musculoskeletal and Skin Diseases Research

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [HHS - NIH]

Rhode Island United States

State-Wide

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) (PA-24-141)

Amendment Since initial award the total obligations have increased 53% from $15,000 to $23,000.