R01MH130348

Establishing Network Neuroscience Mechanisms of Efficiency of Evidence Accumulation in a Well-Characterized Sample with Bipolar Disorder: A Multi-Modal Clinical Imaging Study - Abstract

Bipolar disorder is a serious chronic condition, and there is great interest in understanding brain-based mechanisms that contribute to disorder symptoms. In this proposal, we focus on one promising candidate: Efficiency of Evidence Accumulation (EEA). EEA is measured in specialized models from computational psychiatry, and it quantifies a basic neurocognitive ability to accumulate information from a stimulus in noisy conditions in order to select appropriate responses.

Substantial reductions in EEA are found in bipolar disorder, as well as other major psychiatric disorders, and they contribute to impulsivity and disease severity. There is a critical gap in knowledge, however: at the current time, we know little about the brain mechanisms that produce reduced EEA in bipolar disorder, or in any other psychiatric disorder.

In this project, we address this gap using the methods of network neuroscience. Substantial evidence from large datasets strongly supports a flexible network reconfiguration model of EEA. This model says EEA depends on the brain's ability to adaptively reconfigure connectivity patterns of brain networks across cognitive demands and task contexts. The model suggests the novel hypothesis that reduced EEA in bipolar disorder arises from deficits in flexible network reconfiguration.

We test this hypothesis with U. of Michigan's unique Prechter Longitudinal Study of Bipolar Disorder (headed by Co-I McInnis). We study 130 healthy adults and 130 adults with bipolar disorder, who complete a battery of behavioral tasks to measure EEA and a battery of neuroimaging tasks optimized to measure flexibility of brain network reconfiguration.

A centerpiece of our approach is the use of Brain Basis Set (BBS), a multivariate predictive modeling framework. This method lets us "summarize" tens of thousands of changes in connectivity patterns across the brain in terms of a modest number of basic reconfiguration components. BBS lets us identify what networks reconfigure as well as how much they reconfigure. Using BBS, we will quantify brain network reconfiguration deficits in bipolar disorder.

We additionally link deficits in EEA and reduced brain network reconfiguration specifically to an impulsive/affectively-unstable subtype of bipolar disorder and to impulsivity factor scores. Finally, we elucidate the etiology of deficits in task-evoked brain network reconfiguration. We use multivariate methods to delineate how reduced task-evoked network flexibility arises from alterations in the brain's task-free functional and structural architecture.

EEA is a computational metric that rigorously quantifies core neurocognitive deficits in bipolar disorder. This project leverages computational psychiatry, network neuroscience, and multi-modal imaging to delineate brain network mechanisms that underpin EEA. Success here lays the foundation for a broader network neuroscience research program examining impairments in reconfiguration/flexibility of brain networks across multiple disorders, with the aim of pinpointing etiology and identifying potential interventions.

Regents Of The University Of Michigan

NOT APPLICABLE

93.242 - Mental Health Research Grants

National Institute of Mental Health (NIMH) [HHS - NIH]

Ann Arbor, Michigan 481082744 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)

Amendment Since initial award the total obligations have increased 362% from $780,003 to $3,602,294.