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R01MD016082

Project Grant

Overview

Grant Description
Efficacy of a Multi-Level School Intervention for LGBTQ Youth - Project Summary

The goal of this study is to test the efficacy of a theoretically informed, school-based intervention for sexual and gender minority (SGM) adolescents, Proud & Empowered (P&E). Studies have found that SGM students are 8 to 10 times more likely to experience victimization in schools than heterosexuals, with rates even higher among transgender youth. This bias-based victimization, part of which is commonly known as minority stress, has been cited as a participating factor in the substantial behavioral health disparities SGM face when compared to their heterosexual counterparts, such as depression, anxiety, self-harm, and suicidal ideation and attempt.

These disparities are unique to SGM, as when compared to similarly victimized non-SGM peers, victimized SGM adolescents report significantly higher rates of suicide. When schools lack SGM bullying policies, SGM students are more likely to report suicidality than peers in schools with protective policies. Studies also indicate that SGM victimization is more common in schools that lack protective policies and resources such as Gender and Sexuality Alliances (GSAs), SGM-specific antibullying guidelines, teacher and staff training, and openly supportive allies.

Therefore, it is clear that any intervention for SGM youth must simultaneously (a) help SGM youth cope with the effects of minority stress and (b) work to reduce the likelihood of future victimization by addressing school-level factors. The P&E intervention seeks to address these outcomes through a novel multi-level school-based intervention. Supported by nine years of research including an NIH-supported feasibility study conducted at four schools (1R21MD013971), we will determine the intervention's efficacy by completing three specific aims:

1) Determine participant-level efficacy of the intervention in an RCT with 24 schools.
2) Determine the schoolwide intervention effects on (a) reporting of minority stress and behavioral health outcomes among all SGM students and (b) perceptions of school climate (i.e., norms, attitudes, beliefs, bullying behavior toward SGMA, policies) among all students.
3) Examine factors that may affect intervention success (e.g., fidelity of implementation, barriers or facilitators to implementation, school or student characteristics) to prepare the intervention for future dissemination.

Following the completion of all ten P&E sessions, school-level factors will be addressed by student-led implementation of environmental change strategies at the school focused on key domains of school climate: safety, relationships, teaching and learning, and institutional environment.

This innovative R01 application brings together a team of nationally recognized minority stress and prevention science experts and responds to a nationally established public health need for research from the National Academy of Medicine, the National Institutes of Health (NOT-MD-19-001), and the National Gay and Lesbian Task Force.
Funding Goals
NOT APPLICABLE
Place of Performance
Saint Louis, Missouri 63130 United States
Geographic Scope
Single Zip Code
Analysis Notes
Amendment Since initial award the total obligations have increased 378% from $670,632 to $3,204,002.
Washington University was awarded Efficacy of Proud & Empowered Intervention for LGBTQ Youth in Schools Project Grant R01MD016082 worth $3,204,002 from National Institute for Minority Health and Health Disparities in January 2022 with work to be completed primarily in Saint Louis Missouri United States. The grant has a duration of 4 years 10 months and was awarded through assistance program 93.307 Minority Health and Health Disparities Research. The Project Grant was awarded through grant opportunity Research Project Grant (Parent R01 Clinical Trial Required).

Status
(Ongoing)

Last Modified 6/22/26

Period of Performance
1/20/22
Start Date
11/30/26
End Date
91.0% Complete

Funding Split
$3.2M
Federal Obligation
$0.0
Non-Federal Obligation
$3.2M
Total Obligated
100.0% Federal Funding
0.0% Non-Federal Funding

Activity Timeline

Interactive chart of timeline of amendments to R01MD016082

Subgrant Awards

Disclosed subgrants for R01MD016082

Transaction History

Modifications to R01MD016082

Additional Detail

Award ID FAIN
R01MD016082
SAI Number
R01MD016082-2251963521
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NE00 NIH National Insitute on Minority Health and Healh Disparities
Funding Office
75NE00 NIH National Insitute on Minority Health and Healh Disparities
Awardee UEI
L6NFUM28LQM5
Awardee CAGE
2B003
Performance District
MO-01
Senators
Joshua Hawley
Eric Schmitt

Budget Funding

Federal Account Budget Subfunction Object Class Total Percentage
National Institute on Minority Health and Health Disparities, National Institutes of Health, Health and Human Services (075-0897) Health research and training Grants, subsidies, and contributions (41.0) $1,335,955 100%
Modified: 6/22/26