R01HL166272
Project Grant
Overview
Grant Description
Multimodality deep phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS) - Project Summary
Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic disorder causing disabling symptoms and substantial loss of productivity. Not all POTS patients are the same, and the causes and significance of different subtypes are not known.
For example, some patients may have abnormal regulation of their immune system while others may have problems with the response of their muscles to activity. Exercise training has been shown to be a beneficial treatment for POTS, but about 25% of patients are unable to complete the exercise program.
Our research study will examine the different types of POTS by systematically and comprehensively studying a large diverse group of patients. This will include careful assessment of symptoms, blood tests, and heart structure as well as a detailed analysis of the muscle response to exercise.
This study will be the first to define the full picture of different POTS subtypes and the relationship between these subtypes. Our studies will allow clinicians to better evaluate and individualize treatment and will guide future POTS research.
Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic disorder causing disabling symptoms and substantial loss of productivity. Not all POTS patients are the same, and the causes and significance of different subtypes are not known.
For example, some patients may have abnormal regulation of their immune system while others may have problems with the response of their muscles to activity. Exercise training has been shown to be a beneficial treatment for POTS, but about 25% of patients are unable to complete the exercise program.
Our research study will examine the different types of POTS by systematically and comprehensively studying a large diverse group of patients. This will include careful assessment of symptoms, blood tests, and heart structure as well as a detailed analysis of the muscle response to exercise.
This study will be the first to define the full picture of different POTS subtypes and the relationship between these subtypes. Our studies will allow clinicians to better evaluate and individualize treatment and will guide future POTS research.
Funding Goals
TO FOSTER HEART AND VASCULAR RESEARCH IN THE BASIC, TRANSLATIONAL, CLINICAL AND POPULATION SCIENCES, AND TO FOSTER TRAINING TO BUILD TALENTED YOUNG INVESTIGATORS IN THESE AREAS, FUNDED THROUGH COMPETITIVE RESEARCH TRAINING GRANTS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, USE SMALL BUSINESS TO MEET FEDERAL RESEARCH AND DEVELOPMENT NEEDS, FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY SOCIALLY AND ECONOMICALLY DISADVANTAGED PERSONS, AND INCREASE PRIVATE-SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE R&D BETWEEN SMALL BUSINESSES AND RESEARCH INSTITUTIONS, AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Dallas,
Texas
753907208
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 1484% from $273,762 to $4,336,438.
The University Of Texas Southwestern Medical Center was awarded
Comprehensive Study on POTS Subtypes for Personalized Treatment
Project Grant R01HL166272
worth $4,336,438
from National Heart Lung and Blood Institute in September 2023 with work to be completed primarily in Dallas Texas United States.
The grant
has a duration of 4 years 9 months and
was awarded through assistance program 93.837 Cardiovascular Diseases Research.
The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 7/25/25
Period of Performance
9/15/23
Start Date
6/30/28
End Date
Funding Split
$4.3M
Federal Obligation
$0.0
Non-Federal Obligation
$4.3M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R01HL166272
Transaction History
Modifications to R01HL166272
Additional Detail
Award ID FAIN
R01HL166272
SAI Number
R01HL166272-1990288160
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Funding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Awardee UEI
YZJ6DKPM4W63
Awardee CAGE
1CNP4
Performance District
TX-30
Senators
John Cornyn
Ted Cruz
Ted Cruz
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,000,000 | 59% |
| National Heart, Lung, and Blood Institute, National Institutes of Health, Health and Human Services (075-0872) | Health research and training | Grants, subsidies, and contributions (41.0) | $410,644 | 24% |
| National Institute of Neurological Disorders and Stroke, National Institutes of Health, Health and Human Services (075-0886) | Health research and training | Grants, subsidies, and contributions (41.0) | $273,762 | 16% |
Modified: 7/25/25