R01HL162574
Project Grant
Overview
Grant Description
Psychosocial and Genetic Effects on Gene Expression and Asthma - Abstract
In the past 8 years, we have studied a cohort of youth from metropolitan Detroit to investigate the effects of psychosocial stressors and resources on health, with a specific focus on asthma symptoms (Asthma in the Lives of Families Today, ALOFT study).
Our preliminary results from bulk RNA-seq analysis in peripheral leukocytes demonstrate that psychosocial factors are associated with transcriptional changes for a large number of genes, many of them involved in immunological functions. Importantly, we and others have uncovered an important role for blood cell type composition in inter-individual variation in response to psychosocial environments and their effects on immunological health and asthma symptoms.
Here, we propose:
1) To disentangle the contribution of psychosocial factors and asthmatic state on patterns of transcriptional dysregulation;
2) To investigate the effects of psychosocial factors on transcriptional regulation in blood cell type subpopulations; and
3) To determine the role of genetic variation in modulating these effects and their consequences for asthmatic children's health.
To this end, we will use a combination of bulk and single-cell RNA-sequencing on immune cells collected from children with asthma and their asymptomatic siblings. The complementary expertise of our team will uncover specific genetic and psychosocial factors associated with increased risk for poor physical health and well-being.
These results will be important to design personalized medical and behavioral interventions to alleviate disease severity in children with asthma.
In the past 8 years, we have studied a cohort of youth from metropolitan Detroit to investigate the effects of psychosocial stressors and resources on health, with a specific focus on asthma symptoms (Asthma in the Lives of Families Today, ALOFT study).
Our preliminary results from bulk RNA-seq analysis in peripheral leukocytes demonstrate that psychosocial factors are associated with transcriptional changes for a large number of genes, many of them involved in immunological functions. Importantly, we and others have uncovered an important role for blood cell type composition in inter-individual variation in response to psychosocial environments and their effects on immunological health and asthma symptoms.
Here, we propose:
1) To disentangle the contribution of psychosocial factors and asthmatic state on patterns of transcriptional dysregulation;
2) To investigate the effects of psychosocial factors on transcriptional regulation in blood cell type subpopulations; and
3) To determine the role of genetic variation in modulating these effects and their consequences for asthmatic children's health.
To this end, we will use a combination of bulk and single-cell RNA-sequencing on immune cells collected from children with asthma and their asymptomatic siblings. The complementary expertise of our team will uncover specific genetic and psychosocial factors associated with increased risk for poor physical health and well-being.
These results will be important to design personalized medical and behavioral interventions to alleviate disease severity in children with asthma.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Detroit,
Michigan
48201
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 379% from $695,414 to $3,331,412.
Wayne State University was awarded
Psychosocial Effects on Gene Expression in Asthma - ALOFT Study
Project Grant R01HL162574
worth $3,331,412
from National Heart Lung and Blood Institute in March 2022 with work to be completed primarily in Detroit Michigan United States.
The grant
has a duration of 4 years 9 months and
was awarded through assistance program 93.837 Cardiovascular Diseases Research.
The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/5/26
Period of Performance
3/15/22
Start Date
12/31/26
End Date
Funding Split
$3.3M
Federal Obligation
$0.0
Non-Federal Obligation
$3.3M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R01HL162574
Transaction History
Modifications to R01HL162574
Additional Detail
Award ID FAIN
R01HL162574
SAI Number
R01HL162574-2777559964
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Funding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Awardee UEI
M6K6NTJ2MNE5
Awardee CAGE
2B019
Performance District
MI-13
Senators
Debbie Stabenow
Gary Peters
Gary Peters
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Heart, Lung, and Blood Institute, National Institutes of Health, Health and Human Services (075-0872) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,366,101 | 100% |
Modified: 6/5/26