R01HL162102

Menstrual-Phase-Dependent Differences in Response to Chronic Variable Sleep Loss - Summary

It is well known that sleep loss is associated with significant short- and long-term health consequences, but to date, the impact of sex differences in response to sleep loss are poorly understood. We and others have shown that women have greater neurobehavioral performance impairment than men when exposed to one night of acute sleep loss. Furthermore, when this effect is examined separately by menstrual cycle phase, women in the follicular phase exhibit greater impairment compared to both men and women during the luteal phase, suggesting a possible endocrine mechanism. Indeed, we have shown that these differences in performance may be driven by sex-steroid-mediated changes in core body temperature (CBT), specifically involving the ratio of progesterone (P4) to estradiol (E2) between the follicular and luteal phases. These findings have important implications for understanding the interactions of sleep loss and female sex hormones on neurobehavioral performance and other health consequences.

An important open question, however, is how these menstrual-phase-dependent differences impact performance under more realistic patterns of chronic sleep loss. Millions of women routinely obtain less than the recommended 7-9 hours of sleep per night during the week and attempt to catch up on sleep on the weekend. In men, we have shown that any apparent improvement during such recovery sleep is transient, and that subsequent sleep loss results in more accelerated deterioration in performance. It is unknown how this variable pattern of chronic sleep loss and recovery sleep impacts performance in women during the follicular and luteal phases of the menstrual cycle. The proposed work will fill this important gap in knowledge.

In our proposed 11-day inpatient study, healthy premenopausal women will be randomized to either chronic variable sleep deficiency (with a repeated pattern of two nights of 3 hours time-in-bed followed by one night of 10 hours time-in-bed, equivalent to our prior study in mean) or a sleep satiation control (10 hours time-in-bed throughout) during either the follicular or luteal phase of their menstrual cycle. This protocol will allow us to quantify both the impact of chronic variable sleep deficiency on neurobehavioral performance in women and differences in the response to chronic variable sleep loss across the menstrual cycle. We will also investigate the role of CBT, P4, and E2 in mediating these responses. As an exploratory analysis, we will also evaluate the impact of chronic variable sleep loss on E2 and P4 levels to investigate the effect of insufficient sleep on circulating levels of female sex hormones across the menstrual cycle.

There is immediate

Brigham & Womens Hospital

THE NATIONAL CENTER ON SLEEP DISORDERS RESEARCH (NCSDR) SUPPORTS RESEARCH AND RESEARCH TRAINING RELATED TO SLEEP DISORDERED BREATHING, AND THE FUNDAMENTAL FUNCTIONS OF SLEEP AND CIRCADIAN RHYTHMS. THE CENTER ALSO STEWARDS SEVERAL FORUMS THAT FACILITATE THE COORDINATION OF SLEEP RESEARCH ACROSS NIH, OTHER FEDERAL AGENCIES AND OUTSIDE ORGANIZATIONS, INCLUDING THE SLEEP DISORDERS RESEARCH ADVISORY BOARD AND AN NIH-WIDE SLEEP RESEARCH COORDINATING COMMITTEE. THE CENTER ALSO PARTICIPATES IN THE TRANSLATION OF NEW SLEEP RESEARCH FINDINGS FOR DISSEMINATION TO HEALTH CARE PROFESSIONALS AND THE PUBLIC. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, USE SMALL BUSINESS TO MEET FEDERAL RESEARCH AND DEVELOPMENT NEEDS, FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY SOCIALLY AND ECONOMICALLY DISADVANTAGED PERSONS, AND INCREASE PRIVATE-SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE R&D BETWEEN SMALL BUSINESSES AND RESEARCH INSTITUTIONS, AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D.

93.837 - Cardiovascular Diseases Research

National Heart Lung and Blood Institute (NHLBI) [HHS - NIH]

Boston, Massachusetts 021155804 United States

Single Zip Code

Research Project Grant (Parent R01 Clinical Trial Required) (PA-20-183)

Amendment Since initial award the total obligations have increased 299% from $888,404 to $3,542,937.