R01HL161139
Project Grant
Overview
Grant Description
Prolonged Normothermic Ex Vivo Heart Perfusion (NEVHP) - Abstract
The goal of this project is to establish routinely successful prolonged normothermic ex vivo heart perfusion (NEVHP) leading to organ banks. We have demonstrated routinely successful ex vivo heart perfusion for 24-72 hours using plasma exchange with a paracorporeal animal, then fresh plasma alone, then continuous hemofiltration in sheep and pigs.
The experiments proposed in this application are planned to determine the factors responsible for prolonged NEVHP and demonstrate routine 3-day successful ex vivo perfusion. This would allow heart treatment, verifying heart function, near perfect matching, increase donors, and make heart transplantation elective.
In addition, the NEVHP protocols and systems will be tested to resuscitate hearts after prolonged periods of cold ischemia and hearts from DCD. Critical step prior translated the animal models into clinical practice. Lessons from the research with hearts will apply to other organs.
The goal of this project is to establish routinely successful prolonged normothermic ex vivo heart perfusion (NEVHP) leading to organ banks. We have demonstrated routinely successful ex vivo heart perfusion for 24-72 hours using plasma exchange with a paracorporeal animal, then fresh plasma alone, then continuous hemofiltration in sheep and pigs.
The experiments proposed in this application are planned to determine the factors responsible for prolonged NEVHP and demonstrate routine 3-day successful ex vivo perfusion. This would allow heart treatment, verifying heart function, near perfect matching, increase donors, and make heart transplantation elective.
In addition, the NEVHP protocols and systems will be tested to resuscitate hearts after prolonged periods of cold ischemia and hearts from DCD. Critical step prior translated the animal models into clinical practice. Lessons from the research with hearts will apply to other organs.
Funding Goals
TO FOSTER HEART AND VASCULAR RESEARCH IN THE BASIC, TRANSLATIONAL, CLINICAL AND POPULATION SCIENCES, AND TO FOSTER TRAINING TO BUILD TALENTED YOUNG INVESTIGATORS IN THESE AREAS, FUNDED THROUGH COMPETITIVE RESEARCH TRAINING GRANTS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, USE SMALL BUSINESS TO MEET FEDERAL RESEARCH AND DEVELOPMENT NEEDS, FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY SOCIALLY AND ECONOMICALLY DISADVANTAGED PERSONS, AND INCREASE PRIVATE-SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE R&D BETWEEN SMALL BUSINESSES AND RESEARCH INSTITUTIONS, AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Ann Arbor,
Michigan
481091276
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 287% from $776,002 to $3,004,032.
Regents Of The University Of Michigan was awarded
Optimizing Prolonged Normothermic Ex Vivo Heart Perfusion Organ Banks
Project Grant R01HL161139
worth $3,004,032
from National Heart Lung and Blood Institute in September 2022 with work to be completed primarily in Ann Arbor Michigan United States.
The grant
has a duration of 3 years 9 months and
was awarded through assistance program 93.837 Cardiovascular Diseases Research.
The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/5/25
Period of Performance
9/1/22
Start Date
6/30/26
End Date
Funding Split
$3.0M
Federal Obligation
$0.0
Non-Federal Obligation
$3.0M
Total Obligated
Activity Timeline
Transaction History
Modifications to R01HL161139
Additional Detail
Award ID FAIN
R01HL161139
SAI Number
R01HL161139-2960529389
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Funding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Awardee UEI
GNJ7BBP73WE9
Awardee CAGE
03399
Performance District
MI-06
Senators
Debbie Stabenow
Gary Peters
Gary Peters
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Heart, Lung, and Blood Institute, National Institutes of Health, Health and Human Services (075-0872) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,537,808 | 100% |
Modified: 6/5/25