R01HL160325

Characterizing Sleep, ART Adherence, and Viral Suppression Among Black Sexual Minority Men - Project Summary

To address the aims of the proposed research and RFA-HL-21-018, we will use a syndemics and multi-level approach to investigate relationships between sleep and HIV treatment outcomes and behaviors (e.g., viral suppression and retention in care) cross-sectionally and longitudinally among Black gay, bisexual, and other sexual minority men (SMM) followed over one year to inform interventions.

We will enroll 250 Black SMM from the NIH-funded Neighborhoods and Networks (N2) cohort study in the proposed N2 Sleep Health Study to address the aims of the research. Eligibility requirements include being HIV-seropositive and self-reported willingness to wear a wrist actigraph for two weeks at three points over the course of a year.

In this longitudinal study, after completing the initial 2-week wrist actigraphy protocol, participants will carry the wrist actigraph for an additional 2 weeks every six months over the one-year study period—for a total of three times.

Objectively measured sleep data at baseline could potentially influence decision-making regarding HIV treatment (e.g., antiretroviral treatment [ART] outcomes) over time, providing a clear temporal ordering and an ability to consider potential time-lags. Multi-level factors—e.g., individual-level obesity, intimate partner violence, and spatial proximity to healthcare services—may modify these relationships.

The proposed study will be the first objective sleep health study among any population of Black SMM. Findings from the proposed research have significant implications for targeting contextually appropriate sleep and HIV interventions as there is a need for new approaches to inform the next generation of HIV interventions (i.e., long-acting injectables), especially for Black SMM.

The Trustees Of Columbia University In The City Of New York

THE NATIONAL CENTER ON SLEEP DISORDERS RESEARCH (NCSDR) SUPPORTS RESEARCH AND RESEARCH TRAINING RELATED TO SLEEP DISORDERED BREATHING, AND THE FUNDAMENTAL FUNCTIONS OF SLEEP AND CIRCADIAN RHYTHMS. THE CENTER ALSO STEWARDS SEVERAL FORUMS THAT FACILITATE THE COORDINATION OF SLEEP RESEARCH ACROSS NIH, OTHER FEDERAL AGENCIES AND OUTSIDE ORGANIZATIONS, INCLUDING THE SLEEP DISORDERS RESEARCH ADVISORY BOARD AND AN NIH-WIDE SLEEP RESEARCH COORDINATING COMMITTEE. THE CENTER ALSO PARTICIPATES IN THE TRANSLATION OF NEW SLEEP RESEARCH FINDINGS FOR DISSEMINATION TO HEALTH CARE PROFESSIONALS AND THE PUBLIC. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, USE SMALL BUSINESS TO MEET FEDERAL RESEARCH AND DEVELOPMENT NEEDS, FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY SOCIALLY AND ECONOMICALLY DISADVANTAGED PERSONS, AND INCREASE PRIVATE-SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE R&D BETWEEN SMALL BUSINESSES AND RESEARCH INSTITUTIONS, AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D.

93.837 - Cardiovascular Diseases Research

National Heart Lung and Blood Institute (NHLBI) [HHS - NIH]

New York, New York 100323727 United States

Single Zip Code

Using Syndemics to Understand HLBS Disease Emergence and Progression in People with HIV (PWH)(R01 Clinical Trial Not Allowed) (RFA-HL-21-018)

Amendment Since initial award the total obligations have increased 381% from $817,152 to $3,926,963.