R01HL157533

Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis - Project Abstract

The purpose of this proposal is to develop clinical prediction tools to risk stratify patients with pulmonary sarcoidosis. Because the course of sarcoidal inflammation lasts for many years even in those with self-limiting sarcoid, the lack of prognostic indicators upon which to develop a management plan is not a trivial issue for both patient and physician.

Thus, without prognostication tools, clinicians will not be able to improve the longitudinal care they provide for the types of outcomes that are used in the clinic. The conception of this study was motivated by the preliminary data showing that levels of blood protein and RNA transcripts related to interferon inflammation were predictive of future declines in lung function using Cox proportional hazards modeling.

An important feature of the study design is the focus on clinically relevant outcomes and clinical variables so that results can be immediately translated into clinical practice. This goal is realized in Aim 1, in which we will deliver the best performing clinical prediction model that relies only on clinically available data and lab tests to predict a clinical outcome used in pulmonary clinics to define sarcoidosis disease progression. This outcome is a clinically meaningful decline in lung function.

In Aim 2, we will measure the added value of incorporating novel blood-based interferon-related markers into the clinical prediction models. The goal of this aim is to identify which novel markers should be developed and moved into the clinical arena for use in sarcoidosis prognostication.

Finally, in Aim 3, we will apply these models to an important clinical management problem in sarcoidosis, which is identifying the optimal monitoring frequency for a given patient. Addressing this last question is the first step towards being able to better anticipate disease progression before extensive organ damage occurs.

The team of sarcoidosis investigators are highly qualified to execute this study because they have a track record of performing sarcoidosis clinical research, have ongoing collaborations, and have participated in prior studies that involve biospecimen collection from patients, including NIH-sponsored consortium studies.

To execute this study, the investigators will contribute longitudinal biospecimens and clinical data from 357 patients with sarcoidosis that have been enrolled in longitudinal cohorts at centers across the US. Two hundred additional patients will be enrolled and followed for up to 39 months, leading to a total sample size of 557, of which a majority will be African American.

Our team also includes a uniquely qualified biostatistician, Dr. Charles McCulloch, who has pioneered aspects of the longitudinal modeling approach we will be using. Therefore, the proposed aims have a high likelihood of success for tackling this long-overdue clinical problem.

San Francisco Regents Of The University Of California

THE DIVISION OF LUNG DISEASES SUPPORTS RESEARCH AND RESEARCH TRAINING ON THE CAUSES, DIAGNOSIS, PREVENTION, AND TREATMENT OF LUNG DISEASES AND SLEEP DISORDERS. RESEARCH IS FUNDED THROUGH INVESTIGATOR-INITIATED AND INSTITUTE-INITIATED GRANT PROGRAMS AND THROUGH CONTRACT PROGRAMS IN AREAS INCLUDING ASTHMA, BRONCHOPULMONARY DYSPLASIA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CYSTIC FIBROSIS, RESPIRATORY NEUROBIOLOGY, SLEEP AND CIRCADIAN BIOLOGY, SLEEP-DISORDERED BREATHING, CRITICAL CARE AND ACUTE LUNG INJURY, DEVELOPMENTAL BIOLOGY AND PEDIATRIC PULMONARY DISEASES, IMMUNOLOGIC AND FIBROTIC PULMONARY DISEASE, RARE LUNG DISORDERS, PULMONARY VASCULAR DISEASE, AND PULMONARY COMPLICATIONS OF AIDS AND TUBERCULOSIS. THE DIVISION IS RESPONSIBLE FOR MONITORING THE LATEST RESEARCH DEVELOPMENTS IN THE EXTRAMURAL SCIENTIFIC COMMUNITY AS WELL AS IDENTIFYING RESEARCH GAPS AND NEEDS, OBTAINING ADVICE FROM EXPERTS IN THE FIELD, AND IMPLEMENTING PROGRAMS TO ADDRESS NEW OPPORTUNITIES. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, USE SMALL BUSINESS TO MEET FEDERAL RESEARCH AND DEVELOPMENT NEEDS, FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY SOCIALLY AND ECONOMICALLY DISADVANTAGED PERSONS, AND INCREASE PRIVATE-SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE R&D BETWEEN SMALL BUSINESSES AND RESEARCH INSTITUTIONS, AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D.

93.837 - Cardiovascular Diseases Research

National Heart Lung and Blood Institute (NHLBI) [HHS - NIH]

San Francisco, California 941432204 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)

Amendment Since initial award the total obligations have increased 312% from $1,153,760 to $4,751,121.