R01HD116587

Dietary iron requirements in a diverse group of US adults - Project summary/abstract

The dietary reference intakes (DRIs) for iron were first established in 2001, drawing upon the best available data at that time.

However, the committee was limited by the scarcity of studies, with data dating back to the 1950s and involving a relatively small number of subjects from homogenous populations outside the US.

Consequently, the existing DRIs for iron may not accurately reflect the needs of the increasingly diverse US population.

This proposed supplemental study to the Nutrition for Precision Health (NPH) trial powered by the All of Us Research Program will determine dietary iron requirements in a representative sample of US adults.

The proposed study will recruit a large number of participants (N=~300) enrolled in NPH and collect data used to determine iron requirements.

Specific Aim 1 will quantify iron losses and Specific Aim 2 will determine iron bioavailability from 3 different mixed diets typically consumed in the US.

Factors affecting iron loss and iron bioavailability will be explored.

Indicators of iron status will also be added to the NPH protocol.

These data will serve as a crucial resource for informing the necessary updates to the current DRIs for iron, ensuring they accurately reflect the specific needs of the US population.

This study would not be possible without the larger parent study, as it relies on the infrastructure, resources, and diverse participants recruited for the NPH trial.

Data will be integrated with the All of Us database to facilitate future discoveries that may inform public health recommendations and strategies for preventing iron-related health conditions.

Pennington Biomedical Research Center

TO CONDUCT AND SUPPORT LABORATORY RESEARCH, CLINICAL TRIALS, AND STUDIES WITH PEOPLE THAT EXPLORE HEALTH PROCESSES. NICHD RESEARCHERS EXAMINE GROWTH AND DEVELOPMENT, BIOLOGIC AND REPRODUCTIVE FUNCTIONS, BEHAVIOR PATTERNS, AND POPULATION DYNAMICS TO PROTECT AND MAINTAIN THE HEALTH OF ALL PEOPLE. TO EXAMINE THE IMPACT OF DISABILITIES, DISEASES, AND DEFECTS ON THE LIVES OF INDIVIDUALS. WITH THIS INFORMATION, THE NICHD HOPES TO RESTORE, INCREASE, AND MAXIMIZE THE CAPABILITIES OF PEOPLE AFFECTED BY DISEASE AND INJURY. TO SPONSOR TRAINING PROGRAMS FOR SCIENTISTS, DOCTORS, AND RESEARCHERS TO ENSURE THAT NICHD RESEARCH CAN CONTINUE. BY TRAINING THESE PROFESSIONALS IN THE LATEST RESEARCH METHODS AND TECHNOLOGIES, THE NICHD WILL BE ABLE TO CONDUCT ITS RESEARCH AND MAKE HEALTH RESEARCH PROGRESS UNTIL ALL CHILDREN, ADULTS, FAMILIES, AND POPULATIONS ENJOY GOOD HEALTH. THE MISSION OF THE NICHD IS TO ENSURE THAT EVERY PERSON IS BORN HEALTHY AND WANTED, THAT WOMEN SUFFER NO HARMFUL EFFECTS FROM REPRODUCTIVE PROCESSES, AND THAT ALL CHILDREN HAVE THE CHANCE TO ACHIEVE THEIR FULL POTENTIAL FOR HEALTHY AND PRODUCTIVE LIVES, FREE FROM DISEASE OR DISABILITY, AND TO ENSURE THE HEALTH, PRODUCTIVITY, INDEPENDENCE, AND WELL-BEING OF ALL PEOPLE THROUGH OPTIMAL REHABILITATION.

93.865 - Child Health and Human Development Extramural Research

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

Baton Rouge, Louisiana 708084124 United States

Single Zip Code

Research Project Grant (Parent R01 Clinical Trial Required) (PA-20-183)

Amendment Since initial award the total obligations have increased 213% from $636,890 to $1,995,664.