R01HD105656

The Impact of Opioids on Health Outcomes for Hospitalized Infants - Project Summary

Caring for hospitalized infants requires a comprehensive pain control program aimed at reducing and preventing pain. While opioids are commonly used when an infant undergoes a painful procedure, opioids can increase the risk of short- and long-term morbidity.

The duration and type of opioids used for hospitalized infants varies widely between institutions, and such wide variations could impact early childhood development and overall healthcare utilization.

In this study, we will create a novel clinical and developmental dataset by merging the Pediatric Health Information System (PHIS) and the California Perinatal Quality Care Collaborative (CPQCC). This merged dataset will be the first large retrospective, multi-center cohort representing diverse populations of critically ill, hospitalized infants, linking their in-hospital data with long-term neurodevelopmental outcomes.

Using this novel dataset, we will:

1. Identify variations in opioid use associated with neurodevelopmental disability and long-term resource utilization for high-risk infants.
2. Quantify cumulative opioid dosing received associated with neurodevelopmental disability for high-risk infants.
3. Quantify differences in healthcare utilization and costs associated with high vs. low opioid use among high-risk infants.

The expected outcome is a comprehensive understanding of the variations in opioid use for high-risk infants and its impact on neurodevelopment and healthcare utilization. Results will lead to interventions for hospitalized infants aimed at minimizing variation in pain control and will also inform policymakers of a previously unrecognized infant population in need of increased resources to improve clinical and developmental outcomes.

Children's Hospital Los Angeles

TO CONDUCT AND SUPPORT LABORATORY RESEARCH, CLINICAL TRIALS, AND STUDIES WITH PEOPLE THAT EXPLORE HEALTH PROCESSES. NICHD RESEARCHERS EXAMINE GROWTH AND DEVELOPMENT, BIOLOGIC AND REPRODUCTIVE FUNCTIONS, BEHAVIOR PATTERNS, AND POPULATION DYNAMICS TO PROTECT AND MAINTAIN THE HEALTH OF ALL PEOPLE. TO EXAMINE THE IMPACT OF DISABILITIES, DISEASES, AND DEFECTS ON THE LIVES OF INDIVIDUALS. WITH THIS INFORMATION, THE NICHD HOPES TO RESTORE, INCREASE, AND MAXIMIZE THE CAPABILITIES OF PEOPLE AFFECTED BY DISEASE AND INJURY. TO SPONSOR TRAINING PROGRAMS FOR SCIENTISTS, DOCTORS, AND RESEARCHERS TO ENSURE THAT NICHD RESEARCH CAN CONTINUE. BY TRAINING THESE PROFESSIONALS IN THE LATEST RESEARCH METHODS AND TECHNOLOGIES, THE NICHD WILL BE ABLE TO CONDUCT ITS RESEARCH AND MAKE HEALTH RESEARCH PROGRESS UNTIL ALL CHILDREN, ADULTS, FAMILIES, AND POPULATIONS ENJOY GOOD HEALTH. THE MISSION OF THE NICHD IS TO ENSURE THAT EVERY PERSON IS BORN HEALTHY AND WANTED, THAT WOMEN SUFFER NO HARMFUL EFFECTS FROM REPRODUCTIVE PROCESSES, AND THAT ALL CHILDREN HAVE THE CHANCE TO ACHIEVE THEIR FULL POTENTIAL FOR HEALTHY AND PRODUCTIVE LIVES, FREE FROM DISEASE OR DISABILITY, AND TO ENSURE THE HEALTH, PRODUCTIVITY, INDEPENDENCE, AND WELL-BEING OF ALL PEOPLE THROUGH OPTIMAL REHABILITATION.

93.865 - Child Health and Human Development Extramural Research

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

Los Angeles, California 900276062 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)

Amendment Since initial award the total obligations have increased 363% from $666,735 to $3,086,206.