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R01HD105348

Project Grant

Overview

Grant Description
Project Nurture Expansion Study - Project Summary

In the past 20 years, the United States (US) has seen a fourfold increase in the prevalence of maternal substance use disorders during pregnancy. Substance use during pregnancy is associated with adverse maternal and infant health outcomes. Numerous barriers impede the delivery of well-coordinated and high-quality pregnancy and postpartum care for women with substance use disorder. These barriers include a lack of access to obstetrics providers who are comfortable with providing medical care to women with substance use disorders, competing demands from child welfare and necessary medical services, and limited availability of substance use disorder treatment programs that allow children and provide parenting support resources.

A coalition of maternity care providers, substance use treatment agencies, state social service agencies, and Medicaid funding partners in Oregon tested a care model called Project Nurture in three clinics in the Portland area in 2015. Project Nurture combines maternity care, substance use disorder treatment, peer/doula support, and case management in a single setting. Access to these services in a single care setting reduces barriers to care and facilitates increased collaboration among providers, creating a more supportive environment with realistic expectations for mothers. Care is delivered in a non-judgmental and trauma-informed manner, which is important given the high prevalence of stressful life events experienced by women with substance use disorder.

A peer-reviewed study found Project Nurture to be associated with reductions in child maltreatment and placement of children in foster care, as well as increases in prenatal visits. Preliminary data from an independent evaluator also suggest that Project Nurture may reduce preterm births, reduce intensive neonatal care, and increase engagement in substance use disorder treatment. Oregon's governor is expanding Project Nurture to five rural and underserved counties.

The objective of this study is to establish the empirical evidence needed to replicate Project Nurture in other states. While preliminary findings suggest that Project Nurture improves short- and longer-term maternal-infant outcomes, we propose further investigation to answer three critical questions: (1) What are the key elements of Project Nurture associated with improved outcomes? (2) How can these elements be implemented in rural and underserved settings? And (3) What is the effectiveness of Project Nurture in rural regions and when mothers are engaged in methamphetamine and polysubstance use?

Thus, this study is designed to accomplish the following four aims: (1) Assess the effects of Project Nurture on pregnancy, birth, neonatal, and child welfare outcomes; (2) Assess the effect of Project Nurture on healthcare expenditures; (3) Describe implementation of Project Nurture; and (4) Identify critical elements of Project Nurture and support replication and dissemination.

This study will provide state, regional, and organizational leaders the information needed to replicate Project Nurture and create a safe and de-stigmatized care environment for pregnant women living with substance use disorder.
Funding Goals
TO CONDUCT AND SUPPORT LABORATORY RESEARCH, CLINICAL TRIALS, AND STUDIES WITH PEOPLE THAT EXPLORE HEALTH PROCESSES. NICHD RESEARCHERS EXAMINE GROWTH AND DEVELOPMENT, BIOLOGIC AND REPRODUCTIVE FUNCTIONS, BEHAVIOR PATTERNS, AND POPULATION DYNAMICS TO PROTECT AND MAINTAIN THE HEALTH OF ALL PEOPLE. TO EXAMINE THE IMPACT OF DISABILITIES, DISEASES, AND DEFECTS ON THE LIVES OF INDIVIDUALS. WITH THIS INFORMATION, THE NICHD HOPES TO RESTORE, INCREASE, AND MAXIMIZE THE CAPABILITIES OF PEOPLE AFFECTED BY DISEASE AND INJURY. TO SPONSOR TRAINING PROGRAMS FOR SCIENTISTS, DOCTORS, AND RESEARCHERS TO ENSURE THAT NICHD RESEARCH CAN CONTINUE. BY TRAINING THESE PROFESSIONALS IN THE LATEST RESEARCH METHODS AND TECHNOLOGIES, THE NICHD WILL BE ABLE TO CONDUCT ITS RESEARCH AND MAKE HEALTH RESEARCH PROGRESS UNTIL ALL CHILDREN, ADULTS, FAMILIES, AND POPULATIONS ENJOY GOOD HEALTH. THE MISSION OF THE NICHD IS TO ENSURE THAT EVERY PERSON IS BORN HEALTHY AND WANTED, THAT WOMEN SUFFER NO HARMFUL EFFECTS FROM REPRODUCTIVE PROCESSES, AND THAT ALL CHILDREN HAVE THE CHANCE TO ACHIEVE THEIR FULL POTENTIAL FOR HEALTHY AND PRODUCTIVE LIVES, FREE FROM DISEASE OR DISABILITY, AND TO ENSURE THE HEALTH, PRODUCTIVITY, INDEPENDENCE, AND WELL-BEING OF ALL PEOPLE THROUGH OPTIMAL REHABILITATION.
Place of Performance
Portland, Oregon 972393011 United States
Geographic Scope
Single Zip Code
Analysis Notes
Amendment Since initial award the total obligations have increased 391% from $673,376 to $3,304,098.
Oregon Health & Science University was awarded Project Nurture Expansion Study: Improving Maternal-Infant Outcomes Project Grant R01HD105348 worth $3,304,098 from the National Institute of Child Health and Human Development in September 2021 with work to be completed primarily in Portland Oregon United States. The grant has a duration of 5 years and was awarded through assistance program 93.865 Child Health and Human Development Extramural Research. The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).

Status
(Ongoing)

Last Modified 8/20/25

Period of Performance
9/24/21
Start Date
8/31/26
End Date
79.0% Complete

Funding Split
$3.3M
Federal Obligation
$0.0
Non-Federal Obligation
$3.3M
Total Obligated
100.0% Federal Funding
0.0% Non-Federal Funding

Activity Timeline

Interactive chart of timeline of amendments to R01HD105348

Transaction History

Modifications to R01HD105348

Additional Detail

Award ID FAIN
R01HD105348
SAI Number
R01HD105348-2332897794
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NT00 NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development
Funding Office
75NT00 NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development
Awardee UEI
NPSNT86JKN51
Awardee CAGE
0YUJ3
Performance District
OR-01
Senators
Jeff Merkley
Ron Wyden

Budget Funding

Federal Account Budget Subfunction Object Class Total Percentage
National Institute of Child Health and Human Development, National Institutes of Health, Health and Human Services (075-0844) Health research and training Grants, subsidies, and contributions (41.0) $1,318,250 100%
Modified: 8/20/25