R01HD104616

Sleep-Related Behavior and Cortical Activity in Premature Human Infants as Predictors of Developmental Outcomes - Project Summary

Sleep permeates our early existence: a typical human newborn sleeps 16 hours each day, evenly divided between active (REM) sleep and quiet sleep. The relatively high proportion of active sleep in newborns is the foundation for the decades-old hypothesis that active sleep is important for infant brain development.

In considering this hypothesis, it is important to remember that active sleep is a complex state composed of a variety of behavioral and physiological components that emerge and coalesce over development. Thus, it may be that one or more of these components play outsized roles in promoting brain development. One such candidate component is the phasic activity that comprises twitches of the limbs, face, and eyes.

Over the past 15 years, research in infant rats has revealed that sensory feedback from twitching limbs triggers discrete and abundant activity throughout the sensorimotor system, cascading from the spinal cord to the brainstem, cerebellum, thalamus, sensorimotor cortex, and hippocampus. In recent years, with funding from the Gates Foundation and an R21 from NICHD, investigations were extended to full-term human infants over the first seven postnatal months. Using behavioral measures and high-density electroencephalographic (EEG) recordings, this research revealed heretofore unknown features about the spatiotemporal organization of infant sleep and twitching and introduced new developmental milestones and hypotheses.

Here, we propose to extend these efforts to preterm infants for two reasons: preterm infants exhibit an even higher proportion of active sleep than newborn full-term infants, and they are at increased risk for deficits in motor skill, cerebral palsy, autism, and other neurodevelopmental disorders. Thus, we will determine whether twitching can enhance our understanding of the origins and time course of atypical developmental trajectories and guide future interventions.

Very preterm human infants (<32 weeks postmenstrual age) and mildly preterm infants (32-36 weeks postmenstrual age) in the neonatal intensive care unit (NICU) in the Stead Family Children's Hospital at the University of Iowa will be recruited to participate in a longitudinal study spanning the period before (Phase I) and after (Phase II) discharge from the NICU.

Every two weeks during Phase I, sleep behavior will be recorded along with EEG activity and respiratory rate. During Phase II, in the same preterm infants as well as full-term age-matched controls, sleep behavior, EEG activity, and respiratory rate will be recorded three times between one week and six months corrected age. Neurobehavioral and motor skill assessments will be performed at one and six months of age, and clinical follow-up assessments will be performed at two years of age.

Because this study is longitudinal, behavioral and physiological sleep data will be compared in the same infants across Phases I and II and related to developmental outcomes. Ultimately, this project will provide an unprecedented opportunity to understand how sleep and sleep-related behavior contribute to typical and atypical development in early life.

The University Of Iowa

THE EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENTS MISSION IS TO LEAD RESEARCH AND TRAINING TO UNDERSTAND HUMAN DEVELOPMENT, IMPROVE REPRODUCTIVE HEALTH, ENHANCE THE LIVES OF CHILDREN AND ADOLESCENTS, AND OPTIMIZE ABILITIES FOR ALL.

93.865 - Child Health and Human Development Extramural Research

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

Iowa City, Iowa 52242 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)

Amendment Since initial award the total obligations have increased 393% from $626,875 to $3,090,555.