R01HD102975

NEURODEV KENYA: Characterizing the Epidemiology and Etiology of Developmental Disorders on the Kenyan Coast - Project Summary/Abstract.

The NEURODEV KENYA data set will provide an unprecedented opportunity to study the etiology of neurodevelopmental disorders (NDDs) in East Africa, and create a research resource of international value. It will be the first large-scale NDD collection in a rural African setting that is deeply phenotyped and genetically informative, and all data and materials will be made publicly available.

In this application, we propose to conduct extensive analysis of NEURODEV KENYA’s genetic and phenotypic data, beginning in the award’s second year. The analyses will leverage the rich environment at KEMRI and will be intertwined with our proposed capacity building activities (AIM 3).

Through our capacity building activities, we will provide structured training in genetics and genetic data analysis, determine whether to introduce a lymphoblastic cell line (LCL) protocol into NEURODEV KENYA, and determine how to ethically include adults with ID.

We will share all data (e.g. phenotypes, genotypes), and materials (e.g. DNA from blood, possibly LCLs) through the NIH. We will also share outputs through international consortia and a new African NDD research network formalized through this award (AIM 4).

The General Hospital Corporation

TO CONDUCT AND SUPPORT LABORATORY RESEARCH, CLINICAL TRIALS, AND STUDIES WITH PEOPLE THAT EXPLORE HEALTH PROCESSES. NICHD RESEARCHERS EXAMINE GROWTH AND DEVELOPMENT, BIOLOGIC AND REPRODUCTIVE FUNCTIONS, BEHAVIOR PATTERNS, AND POPULATION DYNAMICS TO PROTECT AND MAINTAIN THE HEALTH OF ALL PEOPLE. TO EXAMINE THE IMPACT OF DISABILITIES, DISEASES, AND DEFECTS ON THE LIVES OF INDIVIDUALS. WITH THIS INFORMATION, THE NICHD HOPES TO RESTORE, INCREASE, AND MAXIMIZE THE CAPABILITIES OF PEOPLE AFFECTED BY DISEASE AND INJURY. TO SPONSOR TRAINING PROGRAMS FOR SCIENTISTS, DOCTORS, AND RESEARCHERS TO ENSURE THAT NICHD RESEARCH CAN CONTINUE. BY TRAINING THESE PROFESSIONALS IN THE LATEST RESEARCH METHODS AND TECHNOLOGIES, THE NICHD WILL BE ABLE TO CONDUCT ITS RESEARCH AND MAKE HEALTH RESEARCH PROGRESS UNTIL ALL CHILDREN, ADULTS, FAMILIES, AND POPULATIONS ENJOY GOOD HEALTH. THE MISSION OF THE NICHD IS TO ENSURE THAT EVERY PERSON IS BORN HEALTHY AND WANTED, THAT WOMEN SUFFER NO HARMFUL EFFECTS FROM REPRODUCTIVE PROCESSES, AND THAT ALL CHILDREN HAVE THE CHANCE TO ACHIEVE THEIR FULL POTENTIAL FOR HEALTHY AND PRODUCTIVE LIVES, FREE FROM DISEASE OR DISABILITY, AND TO ENSURE THE HEALTH, PRODUCTIVITY, INDEPENDENCE, AND WELL-BEING OF ALL PEOPLE THROUGH OPTIMAL REHABILITATION.

93.865 - Child Health and Human Development Extramural Research

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

Boston, Massachusetts 021142621 United States

Single Zip Code

Global Brain and Nervous System Disorders Research Across the Lifespan (R01 Clinical Trials Optional) (PAR-18-835)

Amendment Since initial award the total obligations have increased 8549% from $30,000 to $2,594,590.