R01ES038119

NEIGHBORHOOD AND INDIVIDUAL ENVIRONMENTAL RISK FACTORS IN EARLY LIFE AND -OMICS BIOMARKERS FOR KIDNEY FUNCTION TRAJECTORIES ACROSS CHILDHOOD AND ADULTHOOD - PROJECT SUMMARY/ABSTRACT CHRONIC KIDNEY DISEASE (CKD) AND HYPERTENSION (HTN) ARE SUBSTANTIAL PUBLIC HEALTH CONCERNS IN THE US AND ARE IMPORTANT RISK FACTORS FOR OTHER ADVERSE OUTCOMES INCLUDING ACUTE KIDNEY INJURY AND PREMATURE MORTALITY. CKD AND HTN ARE TYPICALLY DIAGNOSED LATER IN LIFE, YET OUR UNDERSTANDING OF THE PRENATAL AND EARLY LIFE ENVIRON- MENTAL DETERMINANTS OF REDUCED KIDNEY FUNCTION AND HTN ACROSS CHILDHOOD AND EARLY ADULTHOOD REMAINS INCIPI- ENT. THIS RESEARCH, HOWEVER, FACES SEVERAL BARRIERS INCLUDING LACK OF ASSESSMENT OF BOTH NEIGHBORHOOD- AND INDIVIDUAL-LEVEL ENVIRONMENTAL STRESSORS AT SPECIFIC EARLY LIFE STAGES COUPLED WITH LONG-TERM FOLLOW-UP FROM BIRTH TO EARLY ADULTHOOD. THIS PROJECT WILL ADDRESS THESE RESEARCH GAPS BY LEVERAGING HIGH-QUALITY DATA FROM PROJECT VIVA, AN ONGOING LONGITUDINAL PROSPECTIVE PRE-BIRTH COHORT OF MOTHER-CHILD PAIRS FOLLOWED SINCE PREGNANCY. THE OVERALL GOALS OF THE PROPOSED PROJECT ARE TO EXAMINE THE EXTENT TO WHICH EARLY-LIFE EXPOSURE TO DISADVANTAGED NEIGHBORHOOD CONTEXTS AND NEPHROTOXICANTS (I.E., AIR POLLUTANTS AND METALS) LEADS TO LATER LIFE KIDNEY DYSFUNC- TION AND HIGHER BLOOD PRESSURE (BP). THE INVESTIGATORS WILL: (AIM 1) EXAMINE ASSOCIATIONS OF EARLY-LIFE NEIGHBOR- HOOD ENVIRONMENT WITH KIDNEY FUNCTION AND BP ACROSS CHILDHOOD AND EARLY ADULTHOOD; (AIM 2) ASSESS ASSOCIA- TIONS OF INDIVIDUAL-LEVEL EARLY-LIFE EXPOSURE TO CANDIDATE NEPHROTOXICANTS WITH KIDNEY FUNCTION AND BP FROM MID- CHILDHOOD TO EARLY ADULTHOOD; AND (AIM 3) CHARACTERIZE URINARY PROTEOMIC SIGNATURES UNDERLYING ALTERED KIDNEY FUNCTION AND BP TRAJECTORY FROM CHILDHOOD TO EARLY ADULTHOOD, AND EXAMINE THESE SIGNATURES AS POTENTIAL MARK- ERS OF TOXICANT EXPOSURE. THIS INNOVATIVE PROPOSAL WILL BE THE FIRST TO EXAMINE BOTH NEIGHBORHOOD- AND INDIVID- UAL-LEVEL ENVIRONMENTAL DETERMINANTS OF KIDNEY FUNCTION AND BP TRAJECTORIES. WE WILL IDENTIFY ACTIONABLE RISK FAC- TORS AND MOLECULAR SIGNATURES TO IDENTIFY HIGH-RISK INDIVIDUALS AND PINPOINT WHEN PRIMORDIAL PREVENTION EFFORTS HAVE THE GREATEST POTENTIAL TO PREVENT FUTURE CKD AND HTN.

Harvard Pilgrim Health Care

<P>THE GOALS ARE:</P><UL><LI>TO FOSTER FUNDAMENTAL CREATIVE DISCOVERIES, INNOVATIVE RESEARCH STRATEGIES, AND THEIR APPLICATIONS AS A BASIS FOR ULTIMATELY PROTECTING AND IMPROVING HEALTH;</LI><LI>TO DEVELOP, MAINTAIN, AND RENEW SCIENTIFIC HUMAN AND PHYSICAL RESOURCES THAT WILL ENSURE THE NATION'S CAPABILITY TO PREVENT DISEASE;</LI><LI>TO EXPAND THE KNOWLEDGE BASE IN MEDICAL AND ASSOCIATED SCIENCES IN ORDER TO ENHANCE THE NATION'S ECONOMIC WELL-BEING AND ENSURE A CONTINUED HIGH RETURN ON THE PUBLIC INVESTMENT IN RESEARCH; AND</LI><LI>TO EXEMPLIFY AND PROMOTE THE HIGHEST LEVEL OF SCIENTIFIC INTEGRITY, PUBLIC ACCOUNTABILITY, AND SOCIAL RESPONSIBILITY IN THE CONDUCT OF SCIENCE.</LI></UL><P>IN REALIZING THESE GOALS, THE NIH PROVIDES LEADERSHIP AND DIRECTION TO PROGRAMS DESIGNED TO IMPROVE THE HEALTH OF THE NATION BY CONDUCTING AND SUPPORTING RESEARCH:</P><UL><LI>IN THE CAUSES, DIAGNOSIS, PREVENTION, AND CURE OF HUMAN DISEASES;</LI><LI>IN THE PROCESSES OF HUMAN GROWTH AND DEVELOPMENT;</LI><LI>IN THE BIOLOGICAL EFFECTS OF ENVIRONMENTAL CONTAMINANTS;</LI><LI>IN THE UNDERSTANDING OF MENTAL, ADDICTIVE AND PHYSICAL DISORDERS; AND</LI><LI>IN DIRECTING PROGRAMS FOR THE COLLECTION, DISSEMINATION, AND EXCHANGE OF INFORMATION IN MEDICINE AND HEALTH, INCLUDING THE DEVELOPMENT AND SUPPORT OF MEDICAL LIBRARIES AND THE TRAINING OF MEDICAL LIBRARIANS AND OTHER HEALTH INFORMATION SPECIALISTS.</LI></UL>

93.113 - Environmental Health

National Institute of Environmental Health Sciences (NIEHS) [HHS - NIH]

Boston, Massachusetts 022153369 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-25-301)