R01ES034554
Project Grant
Overview
Grant Description
Gears: Combining Advances in Genomics and Environmental Science to Accelerate Actionable Research and Practice in ASD
Abstract:
This application seeks to establish a network for the investigation of gene-environment interaction in Autism Spectrum Disorder (ASD) and outcomes among people with ASD. Much like the Psychiatric Genetics Consortium launched a unifying infrastructure for scaling genome-wide association studies in ASD, the Combining Advances in Genomics and Environmental Science to Accelerate Actionable Research and Practice in ASD (GEARS) network effort will allow a centralized mechanism for GXE activities in ASD across multiple studies.
Robust evaluation of GXE requires a large sample size, harmonized data on both genetics and the environment, and novel statistical methods for measuring and summarizing environments, genetics, and phenotypes. The GEARS network seeks to compliment work in population studies with experimental models leveraging 3D brain organoids, reflecting multiple ASD-associated genetics backgrounds on which the impact of environmental risk can be evaluated on ASD-relevant neurophysiology endpoints.
Finally, the GEARS network will develop and implement a pipeline for outreach and dissemination of GXE findings. The successes of ASD genomics, emerging environmental evidence, and models of effective network collaborations for large-scale efforts make this the ideal time to create a GXE infrastructure for ASD research.
Our team is uniquely poised to lead the GEARS network, creating this opportunity at scale for the first time, and with a focus on both etiology and health outcomes among people with ASD. We have experience in leading multi-site collaborations, expertise in population and laboratory science, and required partnerships to foster communication across researchers and with the broader ASD community. This translational approach, informed by public health, will lead to improved understanding of both causes and consequences of ASD.
Abstract:
This application seeks to establish a network for the investigation of gene-environment interaction in Autism Spectrum Disorder (ASD) and outcomes among people with ASD. Much like the Psychiatric Genetics Consortium launched a unifying infrastructure for scaling genome-wide association studies in ASD, the Combining Advances in Genomics and Environmental Science to Accelerate Actionable Research and Practice in ASD (GEARS) network effort will allow a centralized mechanism for GXE activities in ASD across multiple studies.
Robust evaluation of GXE requires a large sample size, harmonized data on both genetics and the environment, and novel statistical methods for measuring and summarizing environments, genetics, and phenotypes. The GEARS network seeks to compliment work in population studies with experimental models leveraging 3D brain organoids, reflecting multiple ASD-associated genetics backgrounds on which the impact of environmental risk can be evaluated on ASD-relevant neurophysiology endpoints.
Finally, the GEARS network will develop and implement a pipeline for outreach and dissemination of GXE findings. The successes of ASD genomics, emerging environmental evidence, and models of effective network collaborations for large-scale efforts make this the ideal time to create a GXE infrastructure for ASD research.
Our team is uniquely poised to lead the GEARS network, creating this opportunity at scale for the first time, and with a focus on both etiology and health outcomes among people with ASD. We have experience in leading multi-site collaborations, expertise in population and laboratory science, and required partnerships to foster communication across researchers and with the broader ASD community. This translational approach, informed by public health, will lead to improved understanding of both causes and consequences of ASD.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Place of Performance
Baltimore,
Maryland
212182608
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 2678% from $250,000 to $6,943,814.
The Johns Hopkins University was awarded
GEARS: Advancing Genomics and Environmental Science for ASD Research
Project Grant R01ES034554
worth $6,943,814
from the National Institute of Neurological Disorders and Stroke in September 2022 with work to be completed primarily in Baltimore Maryland United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
The Project Grant was awarded through grant opportunity Autism Centers of Excellence: Networks (R01 Clinical Trial Optional).
Status
(Ongoing)
Last Modified 8/20/24
Period of Performance
9/6/22
Start Date
8/31/27
End Date
Funding Split
$6.9M
Federal Obligation
$0.0
Non-Federal Obligation
$6.9M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R01ES034554
Transaction History
Modifications to R01ES034554
Additional Detail
Award ID FAIN
R01ES034554
SAI Number
R01ES034554-68917102
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NV00 NIH NATIONAL INSTITUTE OF ENVIROMENTAL HEALTH SCIENCES
Funding Office
75NQ00 NIH NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Awardee UEI
FTMTDMBR29C7
Awardee CAGE
5L406
Performance District
MD-07
Senators
Benjamin Cardin
Chris Van Hollen
Chris Van Hollen
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Environmental Health Sciences, National Institutes of Health, Health and Human Services (075-0862) | Health research and training | Grants, subsidies, and contributions (41.0) | $3,395,233 | 72% |
| National Institute of Neurological Disorders and Stroke, National Institutes of Health, Health and Human Services (075-0886) | Health research and training | Grants, subsidies, and contributions (41.0) | $800,000 | 17% |
| National Institute of Child Health and Human Development, National Institutes of Health, Health and Human Services (075-0844) | Health research and training | Grants, subsidies, and contributions (41.0) | $500,000 | 11% |
Modified: 8/20/24