R01ES034433
Project Grant
Overview
Grant Description
Early life household air pollution, metal composition and cardiovascular health: evidence from graphs - project summary
In low- and middle-income countries, approximately 2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M DALYs in 2019. The largest proportion of HAP-attributable deaths are due to cardiovascular disease.
Establishment of cardiovascular health in childhood is critical to reduce risk for future cardiovascular disease. We hypothesize that early life (prenatal to age 1) exposure to HAP alters cardiovascular development and programs future disease risk. We further hypothesize that the metal composition of air pollution drives toxicity.
We propose to build on an existing pregnancy cohort in Ghana – the Ghana Randomized Air Pollution and Health Study, or GRAPHS – to assess how early life air pollution exposure and metals exposures affect cardiovascular health through age 12 years. We will use well-established, validated methods to assess these outcomes.
In the long run, our research will help build the evidence base for cost-effective interventions to improve health by reducing HAP exposure.
In low- and middle-income countries, approximately 2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M DALYs in 2019. The largest proportion of HAP-attributable deaths are due to cardiovascular disease.
Establishment of cardiovascular health in childhood is critical to reduce risk for future cardiovascular disease. We hypothesize that early life (prenatal to age 1) exposure to HAP alters cardiovascular development and programs future disease risk. We further hypothesize that the metal composition of air pollution drives toxicity.
We propose to build on an existing pregnancy cohort in Ghana – the Ghana Randomized Air Pollution and Health Study, or GRAPHS – to assess how early life air pollution exposure and metals exposures affect cardiovascular health through age 12 years. We will use well-established, validated methods to assess these outcomes.
In the long run, our research will help build the evidence base for cost-effective interventions to improve health by reducing HAP exposure.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
New York,
New York
100296504
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 449% from $618,733 to $3,394,482.
Icahn School Of Medicine At Mount Sinai was awarded
HAP & Metal Exposure Effects on Child Cardiovascular Health
Project Grant R01ES034433
worth $3,394,482
from the National Institute of Environmental Health Sciences in September 2022 with work to be completed primarily in New York New York United States.
The grant
has a duration of 4 years 9 months and
was awarded through assistance program 93.113 Environmental Health.
The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 7/6/26
Period of Performance
9/7/22
Start Date
6/30/27
End Date
Funding Split
$3.4M
Federal Obligation
$0.0
Non-Federal Obligation
$3.4M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R01ES034433
Transaction History
Modifications to R01ES034433
Additional Detail
Award ID FAIN
R01ES034433
SAI Number
R01ES034433-1689600485
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NV00 NIH National Institute of Enviromental Health Sciences
Funding Office
75NV00 NIH National Institute of Enviromental Health Sciences
Awardee UEI
C8H9CNG1VBD9
Awardee CAGE
1QSQ9
Performance District
NY-13
Senators
Kirsten Gillibrand
Charles Schumer
Charles Schumer
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Environmental Health Sciences, National Institutes of Health, Health and Human Services (075-0862) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,772,080 | 100% |
Modified: 7/6/26