R01EB031114

Portable, low field brain magnetic resonance imaging (MRI) for acute stroke - Abstract.

Neuroimaging is a cornerstone of patient care for patients with brain injury. High field magnets and access to imaging interpretation have prevented magnetic resonance imaging (MRI) from becoming a universally available tool.

Our group has demonstrated the feasibility of acquiring clinically useful images on a portable, low-field MRI. In this proposal, we will validate the use and successful deployment of a portable, mobile MRI into the acute stroke setting.

In current practice, all patients, including those that are critically ill, must be transported to a centralized, controlled-access environment to obtain an MRI at a single time point, in a highly inaccessible paradigm.

Our hypothesis is that a highly portable, low-field MRI can be deployed into nearly any setting on a platform that provides real-time, automated neuroimaging analysis.

Development of this solution incorporates engineering and technological innovation (low field MRI), methodological innovation (imaging reconstruction techniques, machine learning approaches to automated diagnosis), and conceptual innovation (changing clinical workflow to accommodate a non-invasive method capable of point-of-care and serial MRI).

Our key rationale is that we can expand already available treatments, facilitate decision making, and inform new approaches to patient care when we reposition the availability of MRI on a near-universal scale.

The fundamental insight is that a low field, portable MRI solution, including advanced methods in image quality, reconstruction, and interpretation, can make imaging available to virtually any patient. We will bring MRI technology and interpretation to an individual patient's bedside and, in doing so, create a platform for MR imaging and analysis on an unprecedented scale.

Because the instrument is inexpensive, does not have cooling requirements, and operates on a standard 15A 120V electrical source, project success would democratize diagnostic MR imaging for ischemic and hemorrhagic stroke.

In this proposal, we will develop, quantify, and validate the measure of certainty required for transition into clinical care. Stroke has been carefully chosen because of the substantial public health burden and existing treatment options that are available but currently limited because of the requirement for acute neuroimaging.

We have developed a highly collaborative and multidisciplinary framework, with leading experts in low field MRI, machine learning, stroke, multicenter studies, clinical and translational research. Embedded as well in our team is the expertise to immediately take this exciting solution to a variety of novel settings (e.g. ambulance, low/middle income countries).

Our industry partner, Hyperfine, is the first company in the world to develop a truly portable MRI solution, in collaboration with our academic team over the last three years.

As we prospectively develop, troubleshoot, and fine-tune our solution at two leading institutions (Yale and MGH), we have assembled a broad scientific team to incorporate technological, clinical workflow, and health systems factors so that our solution is ready to deploy in any clinical setting to improve patient care across human health.

Yale Univ

NOT APPLICABLE

93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health

National Institute of Biomedical Imaging and Bioengineering (NIBIB) [HHS - NIH]

New Haven, Connecticut 065103221 United States

Single Zip Code

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Optional) (PAR-18-530)

Amendment Since initial award the End Date has been extended from 12/31/25 to 12/31/26 and the total obligations have increased 437% from $660,576 to $3,545,864.