R01DA057605

Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY) - Abstract

Opioid Use Disorder (OUD) remains a persistent public health crisis and epidemic. In spite of robust national, state, and local public health responses to the epidemic, opioid overdose deaths continue to increase. According to the Centers for Disease Control and Prevention (CDC), out of the 91,799 drug overdose deaths in 2020, the majority (68,630 or 75%) involved opioids, representing a 38% increase from 2019. The burden of opioid overdose deaths in Kentucky is even higher, with a 63% increase from 2019 (N=1,036) to 2020 (N=1,688).

In the context of the dynamically changing opioid epidemic, complicated by the challenges presented by the COVID-19 pandemic, agencies and organizations responsible for monitoring and improving the health of the population need timely state and local data to make critical decisions on resource allocation and targeted responses. These decisions are typically related to a set of evidence-based practices (EBPs) aimed at preventing opioid overdose mortality.

We will harness the infrastructure and methodological expertise at the University of Kentucky (UK) Research Centers, including the Kentucky Injury Prevention and Research Center, the Center on Drug and Alcohol Research, and the Institute for Biomedical Informatics. We will also draw on the experience gained from our work on the Healing Communities Study supported by the National Institute on Drug Abuse, and the Overdose Data to Action Project sponsored by the CDC.

The specific aims of this project are to establish the Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY) - an integrated, population-based, near-real time statewide surveillance system. RADOR-KY will ingest data from multiple state agencies and implement advanced informatics algorithms for fast data processing, data linkage, machine learning, and predictive analytics. This will shorten the time between data capture and when analytical results are available to support opioid overdose prevention and control.

RADOR-KY will have mobile and web-based applications to provide immediate dissemination and access to near-real time community or state-level data, reports, and visual analytics. These will be shared with agencies and community end-users. The RADOR-KY End-User Advisory Group, including partners in state government and local communities, will guide the development of the RADOR-KY reporting and visualization functionality.

RADOR-KY will establish a longitudinal dataset accessible through the RADOR-KY portal and also shared within the HEAL Data Ecosystem. Programming code for implemented algorithms and web-based dashboards will be shared in a public repository to advance the efforts to mitigate the opioid epidemic across the U.S.

University Of Kentucky Research Foundation

TO SUPPORT BASIC AND CLINICAL NEUROSCIENCE, BIOMEDICAL, BEHAVIORAL AND SOCIAL SCIENCE, EPIDEMIOLOGIC, HEALTH SERVICES AND HEALTH DISPARITY RESEARCH. TO DEVELOP NEW KNOWLEDGE AND APPROACHES RELATED TO THE PREVENTION, DIAGNOSIS, TREATMENT, ETIOLOGY, AND CONSEQUENCES OF DRUG ABUSE AND ADDICTION, INCLUDING HIV/AIDS. TO SUPPORT RESEARCH TRAINING AND RESEARCH SCIENTIST DEVELOPMENT. TO SUPPORT DISSEMINATION OF RESEARCH FINDINGS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) LEGISLATION IS INTENDED TO EXPAND AND IMPROVE THE SBIR PROGRAMS TO EMPHASIZE AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF TECHNOLOGY DEVELOPED THROUGH FEDERAL SBIR RESEARCH AND DEVELOPMENT, INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN THE SBIR PROGRAM. THE LEGISLATION INTENDS THAT THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.279 - Drug Abuse and Addiction Research Programs

National Institute on Drug Abuse (NIDA) [HHS - NIH]

Lexington, Kentucky 405060004 United States

Single Zip Code

HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed) (RFA-DA-22-044)

Amendment Since initial award the End Date has been extended from 09/29/25 to 08/31/27 and the total obligations have increased 56% from $3,125,772 to $4,881,729.