R01DA052909

Early life stress, chronic drug use, and neuroplasticity in nonhuman primate models of cocaine abuse: relevance to treatment strategies - Abstract

Despite the risks of adolescent initiation of drug use for lifelong addiction and its tremendous health and societal costs, the neurobiological factors leading to increased vulnerability to substance use disorders (SUDs), including cocaine (COC) use disorder (CUD), are poorly understood.

Early life stress (ELS), including adverse experiences such as childhood maltreatment (MALT), is a major risk factor for psychopathologies like SUDs, anxiety, and depression, which are often comorbid. Indeed, individuals with histories of childhood malt are more vulnerable to COC addiction, and deficits in emotional regulation predispose them to stress-induced relapse, contributing to spiraling of drug taking.

Despite these risks, how ELS and COC abuse during adolescence interact to alter brain development, increasing vulnerability to CUD later in life, has not been elucidated. There are also strong sex differences in progression from initiation of drug use during adolescence (experimentation) to the onset of drug dependence, with women showing increased vulnerability, although the underlying neurobiological mechanisms are unclear.

The goal of this proposal is to examine long-term ELS-related impact and neurobiological mechanisms of increased risk to CUD during adulthood. To accomplish this, we are using a unique and highly translational nonhuman primate (NHP) model of infant malt with adolescence COC self-administration (SA) and addressing sex differences.

The studies proposed here with a cohort of adult macaques that experienced infant malt followed by COC SA during adolescence, and characterized longitudinally since birth, are unparalleled. They will provide information of critical relevance for the Human Healthy Brain and Child Development (HBCD) and Adolescent Brain Cognitive Development (ABCD) NIH studies by examining early risk factors and neurobiological mechanisms for SUDs.

The studies leverage this unique cohort of animals during adulthood to examine the long-term impact of ELS and adolescence COC SA on neurobiology of reward and stress/emotion regulatory circuits following a year of COC abstinence (Aim 1), neurobiological changes in dopamine (DA) and serotonin (5-HT) receptors and functional connectivity (FC) of prefrontal cortex (PFC) with ventral striatum (nucleus accumbens) and amygdala following re-exposure to COC SA (Aim 2), and the rate of recovery of DA and 5-HT receptors and FC during abstinence from long-term COC, to investigate whether it predicts COC-induced relapse and responses to pharmacological interventions targeting DA and 5-HT receptors; PET data will inform personalized medicine approaches (Aim 3).

We hypothesize differential effectiveness of DA and 5-HT receptor compounds (alone vs. mixtures) in malt than control animals, and in females versus males. We propose that ELS, in addition to adolescence COC exposure, leads to the dysregulation of reward and stress/emotional systems typically reported in human psychiatric conditions, resulting in increased risk to CUD in adulthood, in comparison to animals with COC adolescence exposure but no ELS history.

Emory University

TO SUPPORT BASIC AND CLINICAL NEUROSCIENCE, BIOMEDICAL, BEHAVIORAL AND SOCIAL SCIENCE, EPIDEMIOLOGIC, HEALTH SERVICES AND HEALTH DISPARITY RESEARCH. TO DEVELOP NEW KNOWLEDGE AND APPROACHES RELATED TO THE PREVENTION, DIAGNOSIS, TREATMENT, ETIOLOGY, AND CONSEQUENCES OF DRUG ABUSE AND ADDICTION, INCLUDING HIV/AIDS. TO SUPPORT RESEARCH TRAINING AND RESEARCH SCIENTIST DEVELOPMENT. TO SUPPORT DISSEMINATION OF RESEARCH FINDINGS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) LEGISLATION IS INTENDED TO EXPAND AND IMPROVE THE SBIR PROGRAMS TO EMPHASIZE AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF TECHNOLOGY DEVELOPED THROUGH FEDERAL SBIR RESEARCH AND DEVELOPMENT, INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN THE SBIR PROGRAM. THE LEGISLATION INTENDS THAT THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.279 - Drug Abuse and Addiction Research Programs

National Institute on Drug Abuse (NIDA) [HHS - NIH]

Georgia United States

State-Wide

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)

Amendment Since initial award the total obligations have increased 380% from $827,551 to $3,974,079.