R01DA051573

Social Influences on Choices in Adolescent Substance Use - Project Summary / Abstract

In the United States, substance use behaviors contribute to the leading causes of mortality and morbidity of adolescents, and are associated with approximately $60 billion in economic costs per year. Negative peer influence is a major environmental risk factor for early initiation of substance use and other risky behaviors. However, group-based interventions and positive social supports are also beneficial for successful cessation of substance use and addictive behaviors. Thus, social influences can contribute to adaptive or maladaptive decision-making and depend on the context and nature of the influence.

Despite the strong contribution of peer influence to individuals' risky (or safe) decision-making, the mechanistic processes underlying susceptibility and resilience to social influence have received limited investigation. Here, we combine a longitudinal cohort design, functional neuroimaging, novel behavioral economic paradigms, and a model-based approach to examine whether substance use, and changes in substance use, are related to individual differences in two mechanisms by which social information influences risky decision-making (Aims 1 & 2).

To test the extent to which changes in substance use may also impact susceptibility to social influence, we will further examine reciprocal effects of substance use on the mechanisms of social influence over time (Aim 3). Our broad hypothesis is that biases in neural and behavioral processing of information from social others contribute to the development of substance use behaviors in adolescents and may explain why social others have an unusually large impact on certain adolescents' decisions to engage in substance use.

Virginia Polytechnic Institute & State University

TO SUPPORT BASIC AND CLINICAL NEUROSCIENCE, BIOMEDICAL, BEHAVIORAL AND SOCIAL SCIENCE, EPIDEMIOLOGIC, HEALTH SERVICES AND HEALTH DISPARITY RESEARCH. TO DEVELOP NEW KNOWLEDGE AND APPROACHES RELATED TO THE PREVENTION, DIAGNOSIS, TREATMENT, ETIOLOGY, AND CONSEQUENCES OF DRUG ABUSE AND ADDICTION, INCLUDING HIV/AIDS. TO SUPPORT RESEARCH TRAINING AND RESEARCH SCIENTIST DEVELOPMENT. TO SUPPORT DISSEMINATION OF RESEARCH FINDINGS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) LEGISLATION IS INTENDED TO EXPAND AND IMPROVE THE SBIR PROGRAMS TO EMPHASIZE AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF TECHNOLOGY DEVELOPED THROUGH FEDERAL SBIR RESEARCH AND DEVELOPMENT, INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN THE SBIR PROGRAM. THE LEGISLATION INTENDS THAT THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.279 - Drug Abuse and Addiction Research Programs

National Institute on Drug Abuse (NIDA) [HHS - NIH]

Roanoke, Virginia 240164950 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)

Amendment Since initial award the total obligations have increased 383% from $719,789 to $3,476,235.