R01CA248551

Establishing Smoke-Free Homes with Families Involved in Child Protective Services: An Effectiveness-Implementation Trial of an Integrated Program - Project Abstract

Child exposure to secondhand smoke (SHS) is linked to multiple forms of cancer throughout the lifespan. Young children living in low-socioeconomic status households are at increased risk for SHS exposure. Families involved with the child protection system as a result of substantiated child maltreatment are an especially high-risk group for SHS, as these families are often living in poverty and report high daily smoking rates. Importantly, child maltreatment victimization also increases the risk of cancer and premature death from cancer, independent of parent smoking behavior. Identifying ways to broadly disseminate effective SHS prevention programs to these high-risk families is an important strategy for reducing cancer disparities.

We propose an effectiveness-implementation hybrid trial type 1 to examine the impact of integrating two evidence-based programs, Some Things Are Better Outside (SHS prevention program) and SafeCare® (child maltreatment prevention program), on establishing a smoke-free home and on implementation process outcomes. Aim 1 focuses on the refinement of the standardized integration (systematic braiding) of the two programs into "Smoke-Free SafeCare (SFSC)." Aims 2 and 3 focus on the hybrid trial.

Fifty certified SafeCare providers will be recruited and randomly assigned to deliver either SFSC or standard SafeCare. Providers will each serve ten research families (N = 500) who meet the inclusion criteria (mother or another person residing in the home smokes at home). The primary outcome, smoke-free home status, will be measured via self-report at 4 timepoints (baseline, 8 weeks, 20 weeks, and 1 year), and validated via air nicotine monitor at 8 weeks and 1 year (Aim 2). Process measures will be collected to examine how the braided intervention impacts provider fidelity, delivery time and costs, and other process measures (Aim 3).

If effective, SFSC can be efficiently disseminated for widespread adoption by the National SafeCare Training and Research Center to the over 100 accredited SafeCare agencies across the United States and worldwide that serve parents involved with child protection services, reducing cancer risk and disparities for a high-risk population.

Georgia State University Research Foundation

TO IDENTIFY CANCER RISKS AND RISK REDUCTION STRATEGIES, TO IDENTIFY FACTORS THAT CAUSE CANCER IN HUMANS, AND TO DISCOVER AND DEVELOP MECHANISMS FOR CANCER PREVENTION AND PREVENTIVE INTERVENTIONS IN HUMANS. RESEARCH PROGRAMS INCLUDE: (1) CHEMICAL, PHYSICAL AND MOLECULAR CARCINOGENESIS, (2) SCREENING, EARLY DETECTION AND RISK ASSESSMENT, INCLUDING BIOMARKER DISCOVERY, DEVELOPMENT AND VALIDATION, (3) EPIDEMIOLOGY, (4) NUTRITION AND BIOACTIVE FOOD COMPONENTS, (5) IMMUNOLOGY AND VACCINES, (6) FIELD STUDIES AND STATISTICS, (7) CANCER CHEMOPREVENTION AND INTERCEPTION, (8) PRE-CLINICAL AND CLINICAL AGENT DEVELOPMENT, (9) ORGAN SITE STUDIES AND CLINICAL TRIALS, (10) HEALTH-RELATED QUALITY OF LIFE AND PATIENT-CENTERED OUTCOMES, AND (11) SUPPORTIVE CARE AND MANAGEMENT OF SYMPTOMS AND TOXICITIES. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO STIMULATE TECHNICAL INNOVATION, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY WOMEN AND SOCIALLY/ECONOMICALLY DISADVANTAGED PERSONS. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING, AND FOSTER PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY WOMEN AND SOCIALLY/ECONOMICALLY DISADVANTAGED PERSONS.

93.393 - Cancer Cause and Prevention Research

National Cancer Institute (NCI) [HHS - NIH]

Atlanta, Georgia 30303 United States

Single Zip Code

Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required) (PAR-18-559)

Amendment Since initial award the End Date has been extended from 12/31/25 to 12/31/26 and the total obligations have increased 414% from $610,645 to $3,138,014.