R01AT013748
Project Grant
Overview
Grant Description
Building a somatosensory atlas for interoception - Project summary/abstract
Somatosensory neurons are well-known for innervating skin and muscle and transmitting sensations such as touch, pain, itch, and proprioception to the brain.
However, these same type of heterogeneous set of neurons also innervate internal organs and are responsible to convey information of the internal state of our body.
These interoceptive signals include both conscious (bladder fullness) and subconscious (blood pressure) senses.
Despite their importance, we do not know their projection patterns and physiological roles.
Here, we propose to use a set of innovative tools that will allow us to specifically label, visualize, and isolate sensory neurons innervating various internal organs.
Using a variety of state-of-art molecular, imaging, and genomic techniques, we will build an anatomical database of these neurons and use SNRNASEQ to establish the molecular identities of individual sensory neurons based on their innervating organs.
Finally, the anatomical, cellular, and molecular maps will be standardized, indexed, and integrated into an atlas that will allow the community to freely access the data.
Somatosensory neurons are well-known for innervating skin and muscle and transmitting sensations such as touch, pain, itch, and proprioception to the brain.
However, these same type of heterogeneous set of neurons also innervate internal organs and are responsible to convey information of the internal state of our body.
These interoceptive signals include both conscious (bladder fullness) and subconscious (blood pressure) senses.
Despite their importance, we do not know their projection patterns and physiological roles.
Here, we propose to use a set of innovative tools that will allow us to specifically label, visualize, and isolate sensory neurons innervating various internal organs.
Using a variety of state-of-art molecular, imaging, and genomic techniques, we will build an anatomical database of these neurons and use SNRNASEQ to establish the molecular identities of individual sensory neurons based on their innervating organs.
Finally, the anatomical, cellular, and molecular maps will be standardized, indexed, and integrated into an atlas that will allow the community to freely access the data.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Place of Performance
La Jolla,
California
920371000
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 102% from $2,804,900 to $5,652,321.
Scripps Research Institute was awarded
Interoception Atlas: Mapping Internal Sensory Neurons Enhanced Understanding
Project Grant R01AT013748
worth $5,652,321
from the National Institute of Allergy and Infectious Diseases in August 2025 with work to be completed primarily in La Jolla California United States.
The grant
has a duration of 4 years 9 months and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Project Grant was awarded through grant opportunity NIH Directors Transformative Research Awards (R01 Clinical Trial Optional).
Status
(Ongoing)
Last Modified 6/5/26
Period of Performance
8/15/25
Start Date
5/31/30
End Date
Funding Split
$5.7M
Federal Obligation
$0.0
Non-Federal Obligation
$5.7M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R01AT013748
Transaction History
Modifications to R01AT013748
Additional Detail
Award ID FAIN
R01AT013748
SAI Number
R01AT013748-1722069294
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Nonprofit With 501(c)(3) IRS Status (Other Than An Institution Of Higher Education)
Awarding Office
75NY00 NIH National Center for Complementary & Integrative Health
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
PHZJFZ32NKH4
Awardee CAGE
08PA3
Performance District
CA-50
Senators
Dianne Feinstein
Alejandro Padilla
Alejandro Padilla
Modified: 6/5/26