R01AR080120
Project Grant
Overview
Grant Description
Focused ultrasound treatment of skin and soft tissue abscesses - Skin and soft tissue infections (SSTIs) are among the most common infections encountered in ambulatory and inpatient settings, with cellulitis and abscess being the most common. Effective treatments are needed as SSTIs are a high-volume condition, and the overall healthcare burden remains high. SSTIs are one of the top causes for hospital readmissions.
Furthermore, the standard of care, incision and drainage (I&D), is one of the most painful procedures in the emergency department. In addition to pain and the potential for unsightly scarring, other complications from I&D include damage to surrounding structures, an extension of the infection into adjacent tissues, bacteremic complications, and recurrence. Furthermore, patient populations with psychosocial risk factors (e.g., homelessness, IV drug use) are prone to secondary infections, and wound care remains problematic in these populations.
Although bacteria can develop drug resistance, they remain susceptible to mechanical damage. In particular, short intense pulses of focused ultrasound (FUS), histotripsy, non-invasively generate localized cavitation that mechanically disrupts the bacteria and represents a new paradigm for non-invasive abscess treatment. We propose that histotripsy can non-invasively disinfect and liquefy many superficial and intramuscular abscesses, allowing for complete fine needle aspiration.
Our aims are to expand our animal model to include MRSA pathogens and perform animal studies to advance this technology toward first-in-human studies. If successful, this approach could decrease patient morbidity, eliminate hospital stays, and lower healthcare costs.
Furthermore, the standard of care, incision and drainage (I&D), is one of the most painful procedures in the emergency department. In addition to pain and the potential for unsightly scarring, other complications from I&D include damage to surrounding structures, an extension of the infection into adjacent tissues, bacteremic complications, and recurrence. Furthermore, patient populations with psychosocial risk factors (e.g., homelessness, IV drug use) are prone to secondary infections, and wound care remains problematic in these populations.
Although bacteria can develop drug resistance, they remain susceptible to mechanical damage. In particular, short intense pulses of focused ultrasound (FUS), histotripsy, non-invasively generate localized cavitation that mechanically disrupts the bacteria and represents a new paradigm for non-invasive abscess treatment. We propose that histotripsy can non-invasively disinfect and liquefy many superficial and intramuscular abscesses, allowing for complete fine needle aspiration.
Our aims are to expand our animal model to include MRSA pathogens and perform animal studies to advance this technology toward first-in-human studies. If successful, this approach could decrease patient morbidity, eliminate hospital stays, and lower healthcare costs.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Seattle,
Washington
981056606
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 391% from $698,992 to $3,433,475.
University Of Washington was awarded
FUS Treatment for SSTIs: Advancing Histotripsy
Project Grant R01AR080120
worth $3,433,475
from the National Institute of Arthritis and Musculoskeletal and Skin Diseases in June 2022 with work to be completed primarily in Seattle Washington United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 5/21/26
Period of Performance
6/15/22
Start Date
5/31/27
End Date
Funding Split
$3.4M
Federal Obligation
$0.0
Non-Federal Obligation
$3.4M
Total Obligated
Activity Timeline
Transaction History
Modifications to R01AR080120
Additional Detail
Award ID FAIN
R01AR080120
SAI Number
R01AR080120-1877004247
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NB00 NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases
Funding Office
75NB00 NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awardee UEI
HD1WMN6945W6
Awardee CAGE
1HEX5
Performance District
WA-07
Senators
Maria Cantwell
Patty Murray
Patty Murray
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Health and Human Services (075-0888) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,397,034 | 100% |
Modified: 5/21/26