R01AR078316
Project Grant
Overview
Grant Description
Sex-Based Muscular Adaptations, Capillary Dysfunction, and Functional Decline Impact Knee-Related Psychosocial Outcomes After Acute Knee Injury (SMACK) - Abstract
Following an anterior cruciate ligament (ACL) reconstruction, females have worse outcomes; however, skeletal muscle biology and function have preferentially been studied in males. These observations suggest that there are sex-based differences in the biological mechanisms contributing to recovery of muscle function.
Intriguing pilot data in this proposal show preferential impairment in the recovery of quadriceps muscle and function and diminished psychosocial recovery in females as compared to males following ACL reconstruction. This proposal seeks to test the novel hypothesis that following an ACL injury, females experience exaggerated muscle cellular and molecular deficits, hindering their recovery of strength, resulting in pronounced deficiencies in gait mechanics and disproportionately worse psychosocial recovery compared to males.
By identifying the cellular and molecular foundation of sex-based differences, subsequent clinical trials can test sex-specific approaches to improve outcomes for women after ACL injury. We will aim to:
1. Define the molecular, cellular, and morphological sex-based differences in quadriceps muscle after ACL injury and reconstruction.
2. Determine the effect of sex on knee function after an ACL reconstruction.
3. Determine the timing and magnitude of psychosocial recovery differences between females and males following an ACL reconstruction.
Results from this work will exert an immediate impact on clinical practice guidelines, as well as identify critical therapeutic targets needed to propel subsequent evidence-based clinical trials designed to improve rehabilitative outcomes for females.
Following an anterior cruciate ligament (ACL) reconstruction, females have worse outcomes; however, skeletal muscle biology and function have preferentially been studied in males. These observations suggest that there are sex-based differences in the biological mechanisms contributing to recovery of muscle function.
Intriguing pilot data in this proposal show preferential impairment in the recovery of quadriceps muscle and function and diminished psychosocial recovery in females as compared to males following ACL reconstruction. This proposal seeks to test the novel hypothesis that following an ACL injury, females experience exaggerated muscle cellular and molecular deficits, hindering their recovery of strength, resulting in pronounced deficiencies in gait mechanics and disproportionately worse psychosocial recovery compared to males.
By identifying the cellular and molecular foundation of sex-based differences, subsequent clinical trials can test sex-specific approaches to improve outcomes for women after ACL injury. We will aim to:
1. Define the molecular, cellular, and morphological sex-based differences in quadriceps muscle after ACL injury and reconstruction.
2. Determine the effect of sex on knee function after an ACL reconstruction.
3. Determine the timing and magnitude of psychosocial recovery differences between females and males following an ACL reconstruction.
Results from this work will exert an immediate impact on clinical practice guidelines, as well as identify critical therapeutic targets needed to propel subsequent evidence-based clinical trials designed to improve rehabilitative outcomes for females.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Lexington,
Kentucky
405060004
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the End Date has been extended from 05/31/26 to 05/31/27 and the total obligations have increased 387% from $647,071 to $3,153,858.
University Of Kentucky Research Foundation was awarded
Sex-Based Muscle Recovery Disparities After ACL Injury - SMACK Study
Project Grant R01AR078316
worth $3,153,858
from the National Institute of Arthritis and Musculoskeletal and Skin Diseases in August 2021 with work to be completed primarily in Lexington Kentucky United States.
The grant
has a duration of 5 years 9 months and
was awarded through assistance program 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/22/26
Period of Performance
8/5/21
Start Date
5/31/27
End Date
Funding Split
$3.2M
Federal Obligation
$0.0
Non-Federal Obligation
$3.2M
Total Obligated
Activity Timeline
Transaction History
Modifications to R01AR078316
Additional Detail
Award ID FAIN
R01AR078316
SAI Number
R01AR078316-1709311045
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NB00 NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases
Funding Office
75NB00 NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awardee UEI
H1HYA8Z1NTM5
Awardee CAGE
5B333
Performance District
KY-06
Senators
Mitch McConnell
Rand Paul
Rand Paul
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Health and Human Services (075-0888) | Health research and training | Grants, subsidies, and contributions (41.0) | $627,834 | 100% |
Modified: 6/22/26