R01AI165483
Project Grant
Overview
Grant Description
Host and Parasite Factors Influencing P. vivax RBC Invasion and Asexual Development - Abstract
Plasmodium vivax threatens half of the world's population and is surprisingly resilient to ongoing malaria elimination efforts, partially due to its unique characteristics and our poor understanding of its biology. Here, we propose to conduct state-of-the-art transcriptomic analyses using materials derived directly from Cambodian patients to rigorously assess the importance of red blood cell polymorphisms, host immunity, and parasite factors in modulating the efficacy of red blood cell invasion and P. vivax intraerythrocytic development.
Our studies will not only provide a better understanding of the fundamental molecular and cellular processes underlying blood stage P. vivax infections but will also provide a solid foundation to develop better malaria vaccines against this important but understudied human pathogen.
Plasmodium vivax threatens half of the world's population and is surprisingly resilient to ongoing malaria elimination efforts, partially due to its unique characteristics and our poor understanding of its biology. Here, we propose to conduct state-of-the-art transcriptomic analyses using materials derived directly from Cambodian patients to rigorously assess the importance of red blood cell polymorphisms, host immunity, and parasite factors in modulating the efficacy of red blood cell invasion and P. vivax intraerythrocytic development.
Our studies will not only provide a better understanding of the fundamental molecular and cellular processes underlying blood stage P. vivax infections but will also provide a solid foundation to develop better malaria vaccines against this important but understudied human pathogen.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Baltimore,
Maryland
21201
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 397% from $660,178 to $3,278,459.
University Of Maryland, Baltimore was awarded
P. vivax Invasion Factors in Cambodian Patients
Project Grant R01AI165483
worth $3,278,459
from the National Institute of Allergy and Infectious Diseases in June 2022 with work to be completed primarily in Baltimore Maryland United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.855 Allergy and Infectious Diseases Research.
The Project Grant was awarded through grant opportunity NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/5/26
Period of Performance
6/8/22
Start Date
5/31/27
End Date
Funding Split
$3.3M
Federal Obligation
$0.0
Non-Federal Obligation
$3.3M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R01AI165483
Transaction History
Modifications to R01AI165483
Additional Detail
Award ID FAIN
R01AI165483
SAI Number
R01AI165483-1341530452
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NM00 NIH National Institute of Allergy and Infectious Diseases
Funding Office
75NM00 NIH National Institute of Allergy and Infectious Diseases
Awardee UEI
Z9CRZKD42ZT1
Awardee CAGE
1B0S2
Performance District
MD-07
Senators
Benjamin Cardin
Chris Van Hollen
Chris Van Hollen
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Allergy and Infectious Diseases, National Institutes of Health, Health and Human Services (075-0885) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,366,494 | 100% |
Modified: 6/5/26