R01AI163398

Spatial Targeting and Adaptive Vector Control for Residual Transmission and Malaria Elimination in Urban African Settings - Project Summary:

The Malaria Control Program on Bioko Island, Equatorial Guinea, was among the vanguard of highly intensive and highly successful malaria control programs in sub-Saharan Africa. Intensive malaria control began in 2004 under the Bioko Island Malaria Control Program (BIMEP), which manages commodity distribution, surveillance, monitoring, and evaluation to eliminate malaria from Bioko Island. However, after initial success, the program has documented slower progress, and malaria persists through residual local transmission by vectors and frequent travel to mainland Equatorial Guinea resulting in malaria importation.

There is a significant need to develop a methodology that would allow BIMEP to improve malaria control through spatial targeting and rapid development of an evidence base to reduce residual transmission and guide elimination efforts across transmission contexts. A practical solution, called Adaptive Vector Control, combines elements of integrated vector control and adaptive management. The overall goal of this proposal is to develop Adaptive Vector Control as a rigorous and quantitative methodology to help programs understand residual transmission, build an evidence base, and identify strategies to suppress residual transmission and eliminate malaria.

The specific goals of Adaptive Vector Control are to quantify residual transmission in the urban setting of Malabo, Bioko Island, the capital of Equatorial Guinea, where 90% of the residents of Bioko Island live, and use that evidence to guide vector control through an iterative, structured policy process. Existing evidence from surveillance, monitoring, and evaluation will be used to develop, validate, and analyze dynamic models of mosquito aquatic habitats, mosquito population dynamics, and malaria transmission in the city. These models will be used to design adaptive sampling and adaptive studies to reduce uncertainty about programmatic decisions. Through simulation-based analytics, the program will improve spatial targeting of indoor residual spraying and larval source management.

Finally, the methods will be used to build an evidence base to support enhanced vector control with novel vector-based interventions to help BIMEP eliminate malaria. The challenges of reducing malaria incidence in Malabo and on Bioko Island are similar to the challenges faced elsewhere in sub-Saharan Africa, and Adaptive Vector Control is one way of addressing the problems of urban vector control in the African context.

University Of Washington

TO ASSIST PUBLIC AND PRIVATE NONPROFIT INSTITUTIONS AND INDIVIDUALS TO ESTABLISH, EXPAND AND IMPROVE BIOMEDICAL RESEARCH AND RESEARCH TRAINING IN INFECTIOUS DISEASES AND RELATED AREAS, TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS. TO ASSIST PUBLIC, PRIVATE AND COMMERCIAL INSTITUTIONS TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS, TO PROVIDE RESEARCH SERVICES AS REQUIRED BY THE AGENCY FOR PROGRAMS IN INFECTIOUS DISEASES, AND CONTROLLING DISEASE CAUSED BY INFECTIOUS OR PARASITIC AGENTS, ALLERGIC AND IMMUNOLOGIC DISEASES AND RELATED AREAS. PROJECTS RANGE FROM STUDIES OF MICROBIAL PHYSIOLOGY AND ANTIGENIC STRUCTURE TO COLLABORATIVE TRIALS OF EXPERIMENTAL DRUGS AND VACCINES, MECHANISMS OF RESISTANCE TO ANTIBIOTICS AS WELL AS RESEARCH DEALING WITH EPIDEMIOLOGICAL OBSERVATIONS IN HOSPITALIZED PATIENTS OR COMMUNITY POPULATIONS AND PROGRESS IN ALLERGIC AND IMMUNOLOGIC DISEASES. BECAUSE OF THIS DUAL FOCUS, THE PROGRAM ENCOMPASSES BOTH BASIC RESEARCH AND CLINICAL RESEARCH. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM EXPANDS AND IMPROVES PRIVATE SECTOR PARTICIPATION IN BIOMEDICAL RESEARCH. THE SBIR PROGRAM INTENDS TO INCREASE AND FACILITATE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATES AND FOSTERS SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. RESEARCH CAREER DEVELOPMENT AWARDS SUPPORT THE DEVELOPMENT OF SCIENTISTS DURING THE FORMATIVE STAGES OF THEIR CAREERS. INDIVIDUAL NATIONAL RESEARCH SERVICE AWARDS (NRSAS) ARE MADE DIRECTLY TO APPROVE APPLICANTS FOR RESEARCH TRAINING IN SPECIFIED BIOMEDICAL SHORTAGE AREAS. IN ADDITION, INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDS ARE MADE TO ENABLE INSTITUTIONS TO SELECT AND MAKE AWARDS TO INDIVIDUALS TO RECEIVE TRAINING UNDER THE AEGIS OF THEIR INSTITUTIONAL PROGRAM.

93.855 - Allergy and Infectious Diseases Research

National Institute of Allergy and Infectious Diseases (NIAID) [HHS - NIH]

Seattle, Washington 981950002 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)

Amendment Since initial award the total obligations have increased 400% from $647,874 to $3,239,370.