R01AG079388

The Black American United Memory & Aging Project (BA-UMAP) is an examination of cognitive decline in midlife and older Black adults using remote cognitive assessments, risk factors, and biomarkers. More research on the multi-level factors impacting the higher prevalence of Alzheimer's disease and related dementias among Black adults is critically needed.

The overall goal of this project is to increase our understanding of the biopsychosocial factors that impact cognitive outcomes in a cohort of 600 longitudinally followed middle-aged and older Black adults (aged 55+). This cohort, referred to as the Black American United Memory and Aging Project (BA-UMAP), will be established and maintained remotely using an innovative online, faceless enrollment and data collection strategy. The project will involve:

(A) A comprehensive assessment of biopsychosocial factors through online questionnaires;
(B) Annual cognitive assessments, administered remotely via computer and mobile devices;
(C) The remote collection of non-invasive saliva and urine samples at baseline and year 4; and
(D) The utilization and integration of digital media platforms for creating a virtual community that provides outreach and education, and fosters trust.

The overall objectives of this study are to:
(1) Prospectively evaluate cognitive functioning and identify preferences for remote cognitive assessment modalities;
(2) Identify sociocultural, behavioral, and environmental factors associated with cross-sectional cognitive functioning and longitudinal cognitive decline; and
(3) Examine the association of acquired biological risk factors, inclusive of family and health history, and salivary and urine biomarkers, to cognitive functioning and cognitive decline.

This research is a necessary step in understanding the etiology of cognitive decline in this growing population, for informing relevant intervention strategies, reducing dementia rates and disparities, and ultimately advancing health equity.

North Carolina Agricultural And Technical State University

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Greensboro, North Carolina 274110002 United States

Single Zip Code

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) (PAR-19-070)

Amendment Since initial award the total obligations have increased 262% from $1,129,418 to $4,085,219.