R01AG079226

Use of Healthcare Across the Full Continuum of Cognitive Health and Decline in Older Adults - Abstract

There are over 6 million individuals with Alzheimer's disease and related dementias (ADRD) in the US, and this number is predicted to triple in the next 30 years. Research indicates that those with dementia have substantially greater healthcare utilization. However, dementia represents only the extreme end of a chronic progressive disorder. Fully characterizing patterns of healthcare utilization across the continuum of cognitive impairment is critical to planning resource use in our aging population and identifying areas where care might be modified or improved.

In particular, better understanding care patterns in the early stages of cognitive impairment could be crucial since modifications may be easier for those with less disease burden. Growing research suggests changes in healthcare utilization may begin even with mild cognitive impairment (MCI). However, the limited studies generally lack rigorous data on cognitive status, integrate health services data from 10-15+ years in the past, or include very small samples.

Thus, we propose to evaluate the spectrum of cognitive health in relation to healthcare utilization, including ADRD drugs and end-of-life (EOL) care, in four ongoing cohorts at the Rush Alzheimer's Disease Center (RADC). All participants receive annual, harmonized cognitive assessments and neurologic exams, with approximately 90% follow-up. This includes 2,317 older individuals with linked Medicare fee-for-service claims from 2010-2019 (11,000 person-years of follow-up: 2,000 person-years for MCI, 1,200 person-years for dementia).

Furthermore, 20% of participants are African American (AA), enabling initial work on cognition and health services focused on AAs, who have a high risk of MCI and dementia. This will also establish a platform for future research as the RADC AA cohort continues to expand.

Briefly, we will compare participants diagnosed as having no cognitive impairment (NCI), MCI, and dementia at each annual cohort evaluation, considering differences in the subsequent year in their utilization of outpatient and inpatient services (Aim 1), and ADRD drug prescription fills (Aim 2). Aim 2 will focus on examining participant and disease characteristics that may be related to prescription fills. In Aim 3, we will compare EOL care across decedents diagnosed with NCI, MCI, or dementia.

Finally, while cohort data are essential to validly studying the continuum of cognition, cohorts often target specific participants. In Aim 4, we will enhance larger translation of cohort findings by assessing any differences in health services, ADRD drugs, and EOL care between RADC participants versus the general Medicare population. We will then apply statistical methods, as needed, to "mimic" our results in larger groups of the general Medicare population.

Impact: By comprehensively evaluating differences in healthcare utilization across the continuum of cognition, we can begin to detect stages where care is accessed differentially, including types of care which may be affected. This will both inform targeted interventions to optimize health services and improve future resource planning.

Rush University Medical Center

NOT APPLICABLE

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Chicago, Illinois 606123833 United States

Single Zip Code

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) (PAR-19-070)

Amendment Since initial award the total obligations have increased 389% from $640,384 to $3,131,402.