R01AG075959

Validation of Video Administration of a Modified UDSV3 Cognitive Battery - Project Summary

This multi-site R01 aims to validate video-administered cognitive assessments for use by the Alzheimer's Disease Research Centers (ADRCs) and other research programs whose activities have been interrupted by the COVID-19 pandemic, as well as for use in future initiatives when remote testing will enhance achievement of scientific goals.

While face-to-face administration is the gold standard for cognitive assessments, conditions often arise that prevent participants from attending in-person visits. These barriers include transportation challenges, limited mobility, and financial hardship. There is also evidence that underserved populations, including rural populations and racial/ethnic minorities, are less likely to enroll in studies that require travel to an academic medical center for face-to-face testing.

The proposed study will address these challenges by utilizing a video-adapted battery incorporating the Uniform Data Set Version 3 (UDSV3) measures with additional measures that may serve as alternatives for UDSV3 measures not adaptable to video administration. We propose to fully validate these assessment tools for remote administration in partnership with the National Institute on Aging (NIA) and the National Alzheimer's Coordinating Center (NACC), and carried out by a consortium of 12 ADRCs.

Pilot data was gathered from 88 Wake Forest ADRC participants, deemed by in-person testing and adjudication to have normal cognition, mild cognitive impairment (MCI), or dementia, who were tested either by phone or video. Data show high participant ratings of tolerability, feasibility, and preference for video versus telephone assessment. There is also high concordance between video-administered and in-person test scores.

Based on this collective data, we plan to fully validate a video-version of the UDSV3 battery in a range of cognitively, ethnically, and geographically diverse participants. We propose to administer remote video cognitive assessments, paired alongside annual in-person cognitive assessments, in counterbalanced order, to 500 existing participants from 12 ADRCs utilizing a computer tablet device, including those previously adjudicated as having normal cognition, MCI, and dementia. Participants' ratings of satisfaction with test condition and preference of test modality will be obtained, in addition to the psychometric characteristics of the video battery relative to face-to-face administration, including concurrent validity, and estimates of relative bias overall and across important subgroups (age, ethnicity, cognitive status) and mode of administration of individual tests. Concordance between adjudication outcomes will also be examined to assess the ability of the battery to distinguish normal cognition, MCI, and dementia.

We will assess the sensitivity of the video battery to detect longitudinal change in cognition in ADRC participants by repeating counterbalanced, in-person and remote assessments 2 years following initial evaluation. Completion of this project is critical to the ongoing success of cognitive assessment in the ADRC network.

Wake Forest University Health Sciences

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Winston Salem, North Carolina 27157 United States

Single Zip Code

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) (PAR-19-070)

Amendment Since initial award the total obligations have increased 261% from $1,467,486 to $5,299,547.