R01AG071707

An Integrated Exercise and Bladder Training Intervention to Reduce Falls in Older Women with Urinary Incontinence - Project Summary/Abstract

Urgency urinary incontinence (UUI) is a biomarker of falls risk and disproportionately affects older minority women living in urban communities. Over 50% of an estimated 10 million women aged 70 and older with UUI will experience a fall. A fall compounds the functional dependency already present in older women with UUI, making their quality of life worse than that following a stroke.

This proposal addresses a key research gap: existing fall prevention interventions cannot be applied to women with UUI, and effective interventions that reduce falls in older community-dwelling women with UUI are lacking. Our objective is to establish the effectiveness of a novel multidimensional intervention to reduce falls in older women with UUI. This intervention is based on the hypothesis that falls in older adult women with urinary incontinence are the result of urinary urgency-related anxiety in the setting of reduced lower limb muscle strength, poor balance, and environmental hazards.

Our trial will show that a tailored intervention that addresses each of these interdependent factors through integrated behavioral bladder training and urge suppression, strength and balance exercises, and home hazard assessment will reduce falls and improve urinary incontinence in older community-dwelling women with UUI. The investigators of this proposal have already developed and validated the intervention in pilot studies and now propose a randomized controlled trial of 314 women to rigorously establish its effectiveness.

Our specific aims are:
1) To determine the effect of a tailored integrated exercise and bladder training intervention on falls in older women.
2) To determine the effect of a tailored integrated exercise and bladder training intervention on urgency urinary incontinence in older women.

The trial will use a community-engagement approach to recruit women living in an urban core community with a high proportion of minorities. This trial will be the first adequately powered study to test an intervention for reducing falls in older community-dwelling women with urgency urinary incontinence and also the first adequately powered study to test the efficacy of a physical exercise intervention for the treatment of urinary incontinence.

This study will have significant public health impact because it will establish the clinical effectiveness of a scalable intervention that targets two common highly morbid conditions: falls and incontinence in older women.

Trustees Of The University Of Pennsylvania

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Pennsylvania United States

State-Wide

Research Project Grant (Parent R01 Clinical Trial Required) (PA-20-183)

Amendment Since initial award the total obligations have increased 376% from $666,434 to $3,172,146.