R01AA028286

Characterizing Individual Differences in the Reciprocal Relationship between Sleep Deprivation and Binge Drinking within the Context of College Life - Abstract

There is strong evidence that maladaptive behaviors, including poor sleep hygiene and binge drinking, emerge in the college environment. When repeated in cycles, the risk of habit development increases, which may contribute to the development of addiction, psychiatric illness, and physical disease. Both chronic sleep deprivation and frequent excessive alcohol use disrupt behavioral and physiological functioning, and their relationship appears reciprocal. However, research on individual differences in the alcohol-sleep relationship is largely unexplored, but it may identify putative biomarkers for immediate and long-term risks of alcohol misuse.

This proposal's public health significance stems from its potential to reduce immediate alcohol-related harms in college students and develop a scientific premise for improving the lives of individuals with sleep and alcohol use disorders. The proposed studies build from an ongoing longitudinal study of college students (R01 AA027017), using its participants, weekly drinking data, and physiological protocols. The study maps the sleep-alcohol relationship onto individual drinking bouts. It pairs self-reported sleep quality with objective measures of sleep behavior (actigraphy) and physiology (polysomnography) that are collected before, during, and after a drinking bout. Sleep is operationalized as a multidimensional and dynamic behavior that is measurable within and across discrete episodes. Self-reported alcohol use and consequences are paired with a cardiovascular reactivity test that objectively assesses proximal physiological repercussions of drinking.

Study 1 (N=150) is a one-week actigraphy study of sleep duration, timing, and fragmentation. Aim 1 focuses on sleep behaviors preceding a drinking event (i.e., pre-intoxication) and assesses how cumulative sleep debt and sleep irregularity influence individual differences in the immediate consequences of drinking measured from self-report and cardiovascular reactivity. Aim 2 targets sleep on the night of a drinking event (i.e., during intoxication) and assesses individual differences in acute alcohol effects on sleep quantity and quality, as well as associations with alcohol use behaviors across the subsequent week and over 2 years.

Study 2 (N=25) involves at-home, overnight polysomnography sessions on a night following a drinking night and on a night that does not follow drinking to assess sleep architecture changes, such as time spent in rapid eye movement (REM) and slow-wave sleep. Aim 3 explores how sleep is altered during recovery (i.e., post-intoxication) from drinking and if individual differences in sleep physiology relate to sleep behavior and cardiovascular physiology.

This application innovates through its use of multi-level assessments of sleep and alcohol use; concurrently collecting objective data may help dissociate contextual influences on self-report. It also innovates with a multi-PI design that ensures primary expertise in both the alcohol and sleep fields. The added value for the proposed studies comes from the resulting intensive, day-level, longitudinal data that has the potential to generate secondary analyses focused on event-level data of within-subject alcohol-sleep relationships across time.

The State University Of New Jersey Rutgers

TO DEVELOP A SOUND FUNDAMENTAL KNOWLEDGE BASE WHICH CAN BE APPLIED TO THE DEVELOPMENT OF IMPROVED METHODS OF TREATMENT AND MORE EFFECTIVE STRATEGIES FOR PREVENTING ALCOHOLISM AND ALCOHOL-RELATED PROBLEMS. THE NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA) SUPPORTS RESEARCH IN A BROAD RANGE OF DISCIPLINES AND SUBJECT AREAS RELATED TO BIOMEDICAL AND GENETIC FACTORS, PSYCHOLOGICAL AND ENVIRONMENTAL FACTORS, ALCOHOL-RELATED PROBLEMS AND MEDICAL DISORDERS, HEALTH SERVICES RESEARCH, AND PREVENTION AND TREATMENT RESEARCH. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION AND TECHNOLOGY TRANSFER THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.273 - Alcohol Research Programs

National Institute on Alcohol Abuse and Alcoholism (NIAAA) [HHS - NIH]

Piscataway, New Jersey 088543987 United States

Single Zip Code

Epidemiology and Prevention in Alcohol Research (R01 - Clinical Trial Optional) (PA-18-390)

Amendment Since initial award the total obligations have increased 401% from $416,251 to $2,085,887.