P50AA030407
Project Grant
Overview
Grant Description
Alcohol Center of Research -- Nebraska (ACORN) - The goal of the Alcohol Center of Research-Nebraska (ACORN) is to expand existing strengths and expertise in Nebraska to develop a novel niche in alcohol research, by creating a center focused on the alcohol exposome.
Alcohol research has been a major area of emphasis in Nebraska (at the Omaha VA Medical Center Research Service and at the University of Nebraska Medical Center) for over 5 decades. As a result, many contributions to the field of alcohol research and the treatment of alcoholic liver disease have been made. Studies examining the effects of alcohol on trace metal metabolism, lung biology and physiology, mechanisms of alcoholic fatty liver, role of aldehyde adducts in alcoholic cell injury, hepatic protein trafficking and signal transduction events, and the role of immune mechanisms in alcoholic liver disease have been some of the key areas of investigation.
Our goal is to translate to humans how factors in the exposome such as age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. We know that a major component of the specific external environment is the lifestyle factor of alcohol consumption. Thus, under the comprehensive schema of the exposome, alcohol represents an environmental exposure that should be considered in context with other internal and external factors to understand causes and nature of disease progression.
The overall hypothesis of our application is the following: the examination of alcohol in the context of the exposome will allow us to understand its role more fully in the etiology of disease and the subsequent manifestations of alcohol-induced human pathophysiology. The alcohol-exposome theme of the center is unique among alcohol centers and has the potential to be highly translational.
Our investigators represent an outstanding team of interdisciplinary investigators that will be supported by an administrative core, a biospecimen core, and a pilot projects core. ACORN investigators will have access to state-of-the-art facilities at UNMC, Nebraska Medical Center, and University of Nebraska-Lincoln. We include faculty from 5 departments and 3 colleges.
Our proposed specific aims for the ACORN are to:
1) Facilitate interdisciplinary research and identify factors so that we can translate in humans how age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration.
2) Create a biospecimen core to aid center investigators in promotion and development of translational animal and human tissue and cell models.
3) Enhance the collaborative ACORN environment and provide opportunities for funding through training, symposia, and pilot grants.
Work on our 4 research projects, with participation of the administration core and the biospecimen core, will allow us to realize our goals. Overall, this new P50 will utilize the expertise and knowledge of past research efforts to examine how alcohol, in the setting of various external and internal environmental factors, will influence disease in a variety of organs and help us shape our future animal and human studies.
Alcohol research has been a major area of emphasis in Nebraska (at the Omaha VA Medical Center Research Service and at the University of Nebraska Medical Center) for over 5 decades. As a result, many contributions to the field of alcohol research and the treatment of alcoholic liver disease have been made. Studies examining the effects of alcohol on trace metal metabolism, lung biology and physiology, mechanisms of alcoholic fatty liver, role of aldehyde adducts in alcoholic cell injury, hepatic protein trafficking and signal transduction events, and the role of immune mechanisms in alcoholic liver disease have been some of the key areas of investigation.
Our goal is to translate to humans how factors in the exposome such as age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. We know that a major component of the specific external environment is the lifestyle factor of alcohol consumption. Thus, under the comprehensive schema of the exposome, alcohol represents an environmental exposure that should be considered in context with other internal and external factors to understand causes and nature of disease progression.
The overall hypothesis of our application is the following: the examination of alcohol in the context of the exposome will allow us to understand its role more fully in the etiology of disease and the subsequent manifestations of alcohol-induced human pathophysiology. The alcohol-exposome theme of the center is unique among alcohol centers and has the potential to be highly translational.
Our investigators represent an outstanding team of interdisciplinary investigators that will be supported by an administrative core, a biospecimen core, and a pilot projects core. ACORN investigators will have access to state-of-the-art facilities at UNMC, Nebraska Medical Center, and University of Nebraska-Lincoln. We include faculty from 5 departments and 3 colleges.
Our proposed specific aims for the ACORN are to:
1) Facilitate interdisciplinary research and identify factors so that we can translate in humans how age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration.
2) Create a biospecimen core to aid center investigators in promotion and development of translational animal and human tissue and cell models.
3) Enhance the collaborative ACORN environment and provide opportunities for funding through training, symposia, and pilot grants.
Work on our 4 research projects, with participation of the administration core and the biospecimen core, will allow us to realize our goals. Overall, this new P50 will utilize the expertise and knowledge of past research efforts to examine how alcohol, in the setting of various external and internal environmental factors, will influence disease in a variety of organs and help us shape our future animal and human studies.
Funding Goals
TO DEVELOP A SOUND FUNDAMENTAL KNOWLEDGE BASE WHICH CAN BE APPLIED TO THE DEVELOPMENT OF IMPROVED METHODS OF TREATMENT AND MORE EFFECTIVE STRATEGIES FOR PREVENTING ALCOHOLISM AND ALCOHOL-RELATED PROBLEMS. THE NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA) SUPPORTS RESEARCH IN A BROAD RANGE OF DISCIPLINES AND SUBJECT AREAS RELATED TO BIOMEDICAL AND GENETIC FACTORS, PSYCHOLOGICAL AND ENVIRONMENTAL FACTORS, ALCOHOL-RELATED PROBLEMS AND MEDICAL DISORDERS, HEALTH SERVICES RESEARCH, AND PREVENTION AND TREATMENT RESEARCH. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION AND TECHNOLOGY TRANSFER THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Nebraska
United States
Geographic Scope
State-Wide
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 51% from $3,139,002 to $4,746,951.
Board Of Regents Of The University Of Nebraska was awarded
ACORN: Advancing Alcohol Research through the Exposome
Project Grant P50AA030407
worth $4,746,951
from National Institute on Alcohol Abuse and Alcoholism in February 2023 with work to be completed primarily in Nebraska United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.273 Alcohol Research Programs.
The Project Grant was awarded through grant opportunity Specialized Alcohol Research Centers (P50 Clinical Trial Optional).
Status
(Ongoing)
Last Modified 1/21/25
Period of Performance
2/28/23
Start Date
1/31/28
End Date
Funding Split
$4.7M
Federal Obligation
$0.0
Non-Federal Obligation
$4.7M
Total Obligated
Activity Timeline
Transaction History
Modifications to P50AA030407
Additional Detail
Award ID FAIN
P50AA030407
SAI Number
P50AA030407-922738526
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75N500 NIH NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
Funding Office
75N500 NIH NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
Awardee UEI
G15AG3BLLMH4
Awardee CAGE
1PPD6
Performance District
NE-90
Senators
Deb Fischer
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Health and Human Services (075-0894) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,569,501 | 100% |
Modified: 1/21/25