P41EB028744

Center for Virtual Imaging Trials - Abstract

The accelerating complexity of medical imaging devices and methods has largely outpaced the field's ability to evaluate and optimize their design and clinical use. Doing so through clinical trials is often not feasible or definitive due to ethical limitations, expense, time requirements, and/or a fundamental lack of ground truth (exact patient anatomy and condition).

Most current approaches to assess imaging technologies outside of clinical trials rely on simplistic models and subjective perception of image aesthetics, and results cannot readily predict clinical efficacy. To fill this gap, the broad objective of the Center for Virtual Imaging Trials is to develop a virtual platform for assessing the effectiveness of medical imaging systems and methods for specific clinical tasks.

The initial focus is on computed tomography (CT), both due to its widespread medical utility and its status as the largest source of medical radiation. Virtual imaging trials offer an efficient means to evaluate imaging concepts and technologies in silico by simulating the patient, imaging system, and image evaluation. Such virtual trials can be conducted quickly and cost-effectively on a computer, providing researchers a practical way to answer fundamental questions using the precise controls and the exact knowledge of a modeled patient. They also enable objective optimization of current and emerging imaging technologies (hardware and software) to minimize radiation risk and provide quantitative accuracy.

By accelerating and improving imaging technologies' evaluation and optimization, virtual trials support quality, safety, and effective practice of patient-centered care. To achieve its objective, the Center will develop, refine, and disseminate the essential resources to realistically model and represent a) patients, b) imaging systems, and c) image evaluation. These resources comprise the three Technology Research and Development (TRD) projects, which work synergistically with and provide resources to Collaborative Projects (CPS) and Service Projects (SPS). A Technology Training and Dissemination (TTD) component will distribute the Center's resources and provide the necessary training. Administration provides infrastructure, oversight, and integration.

The overall specific aims are to (1) develop, consolidate, and streamline the required components to enable virtual imaging trials of existing and emerging CT imaging methods, (2) position virtual trials as an alternative methodology to quantify, evaluate, and optimize CT imaging, and (3) disseminate to the research community validated tools for efficient virtual trials in CT and train researchers to use them effectively.

Using state-of-the-art simulation and analysis methods, the Center will provide the first comprehensive platform to assess the diagnostic capability of imaging technologies in their complete trajectory from design to use. The Center will have a notable impact on rigorous and reproducible scientific design, prediction, and practice of medical imaging, starting with CT, leading to measured reductions in radiation dose, improvements in image quality, and advancement of precision imaging.

Duke University

TO SUPPORT HYPOTHESIS-, DESIGN-, TECHNOLOGY-, OR DEVICE-DRIVEN RESEARCH RELATED TO THE DISCOVERY, DESIGN, DEVELOPMENT, VALIDATION, AND APPLICATION OF TECHNOLOGIES FOR BIOMEDICAL IMAGING AND BIOENGINEERING. THE PROGRAM INCLUDES BIOMATERIALS (BIOMIMETICS, BIOPROCESSING, ORGANOGENESIS, REHABILITATION, TISSUE ENGINEERING, IMPLANT SCIENCE, MATERIAL SCIENCE, INTERFACE SCIENCE, PHYSICS AND STRESS ENGINEERING, TECHNOLOGY ASSESSMENT OF MATERIALS/DEVICES), BIOSENSORS/BIOTRANSDUCERS (TECHNOLOGY DEVELOPMENT, TECHNOLOGY ASSESSMENT, DEVELOPMENT OF ALGORITHMS, TELEMETRY), NANOTECHNOLOGY (NANOSCIENCE, BIOMIMETICS, DRUG DELIVERY SYSTEMS, DRUG BIOAVAILABILITY, MICROARRAY/COMBINATORIAL TECHNOLOGY, GENETIC ENGINEERING, COMPUTER SCIENCE, TECHNOLOGY ASSESSMENT), BIOINFORMATICS (COMPUTER SCIENCE, INFORMATION SCIENCE, MATHEMATICS, BIOMECHANICS, COMPUTATIONAL MODELING AND SIMULATION, REMOTE DIAGNOSIS AND THERAPY), IMAGING DEVICE DEVELOPMENT, BIOMEDICAL IMAGING TECHNOLOGY DEVELOPMENT, IMAGE EXPLOITATION, CONTRAST AGENTS, INFORMATICS AND COMPUTER SCIENCES RELATED TO IMAGING, MOLECULAR AND CELLULAR IMAGING, BIOELECTRICS/BIOMAGNETICS, ORGAN AND WHOLE BODY IMAGING, SCREENING FOR DISEASES AND DISORDERS, AND IMAGING TECHNOLOGY ASSESSMENT AND SURGERY (TECHNIQUE DEVELOPMENT AND TECHNOLOGY DEVELOPMENT).

93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health

National Institute of Biomedical Imaging and Bioengineering (NIBIB) [HHS - NIH]

Durham, North Carolina 277053825 United States

Single Zip Code

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) (PA-20-272)

Amendment Since initial award the total obligations have increased 442% from $1,240,612 to $6,720,916.