P30GM145393

Center for Microbial Pathogenesis and Host Inflammatory Responses - Project Summary/Abstract

The Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR: P20-GM103625) was established at the University of Arkansas for Medical Sciences (UAMS) in 2012. The underlying scientific theme is that addressing existing and emerging problems in infectious disease in a clinically relevant fashion will require an understanding of both the pathogens themselves and how they impact the host immunological and inflammatory response.

This theme is based on the premise that understanding the complex interplay between diverse pathogens and their common human host is a prerequisite to maximizing opportunities to manipulate one or both sides of this equation in favor of the desired prophylactic and/or therapeutic outcome.

In Phases I and II, we assembled a critical mass of investigators around this scientific theme and provided them with the administrative and technical resources they needed to establish successful scientific careers.

In Phase III, we will refine and expand on these efforts with the overall goal of building on our success in Phases I and II to establish a self-sustaining center of biomedical research excellence that focuses on infectious diseases in a comprehensive and clinically relevant fashion.

To this end, the specific aims of this Phase III application are to:

1) Provide an infrastructure that maximizes the competitiveness of CMPHIR investigators through the support of essential core facilities.

2) Promote continued growth of the CMPHIR and career development of its investigators.

3) Transition the CMPHIR to a nationally recognized, self-sustaining center of biomedical research excellence with the expertise and resources to address existing and emerging problems in infectious disease.

University Of Arkansas For Medical Sciences

THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES (NIGMS) SUPPORTS BASIC RESEARCH THAT INCREASES OUR UNDERSTANDING OF BIOLOGICAL PROCESSES AND LAYS THE FOUNDATION FOR ADVANCES IN DISEASE DIAGNOSIS, TREATMENT, AND PREVENTION. NIGMS ALSO SUPPORTS RESEARCH IN SPECIFIC CLINICAL AREAS THAT AFFECT MULTIPLE ORGAN SYSTEMS: ANESTHESIOLOGY AND PERI-OPERATIVE PAIN, CLINICAL PHARMACOLOGY ?COMMON TO MULTIPLE DRUGS AND TREATMENTS, AND INJURY, CRITICAL ILLNESS, SEPSIS, AND WOUND HEALING.? NIGMS-FUNDED SCIENTISTS INVESTIGATE HOW LIVING SYSTEMS WORK AT A RANGE OF LEVELSFROM MOLECULES AND CELLS TO TISSUES AND ORGANSIN RESEARCH ORGANISMS, HUMANS, AND POPULATIONS. ADDITIONALLY, TO ENSURE THE VITALITY AND CONTINUED PRODUCTIVITY OF THE RESEARCH ENTERPRISE, NIGMS PROVIDES LEADERSHIP IN SUPPORTING THE TRAINING OF THE NEXT GENERATION OF SCIENTISTS, ENHANCING THE DIVERSITY OF THE SCIENTIFIC WORKFORCE, AND DEVELOPING RESEARCH CAPACITY THROUGHOUT THE COUNTRY.

93.859 - Biomedical Research and Research Training

National Institute of General Medical Sciences (NIGMS) [HHS - NIH]

Little Rock, Arkansas 722057101 United States

Single Zip Code

Limited Competition: Centers of Biomedical Research Excellence (COBRE) Phase III - Transitional Centers (P30 Clinical Trial Optional) (PAR-20-115)

Amendment Since initial award the total obligations have increased 367% from $1,140,000 to $5,326,094.