P30AI168439

Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) - Texas Biomed IN-TRAC Overall Abstract

The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research Institute (Texas Biomed) will attract the next generation of diverse researchers to the tuberculosis (TB) research field and develop them into independent researchers with multi-disciplinary skills and real-world experience of clinical TB. The product of IN-TRAC will be researchers that choose to work on some of the most challenging and relevant translational problems in TB and that work across academic disciplines and within a framework of highly collaborative research. This will be achieved through 6 interrelated cores.

Administrative Core: The central hub of IN-TRAC management and oversight, with responsibility for administrative and scientific leadership. This core will coordinate communication between cores, researchers, and NIH/NIAID program staff, and provide an organizational structure to optimize multidisciplinary collaborations and interactions between the cores and among a diverse cohort of IN-TRAC participants.

Development Core: This core will oversee all career development programming and courses, tailoring the research and clinical experiences, both intern and externships, to each individual IN-TRAC participant. Additionally, this core will manage the IN-TRAC pilot grant program.

Biosafety & Biocontainment Core: This core will extend the required biosafety training to a personalized curriculum, including theoretical and hands-on biocontainment training. Participants will gain an understanding of the mechanical and regulatory requirements of a BSL3/ABSL3, receive coaching on how to develop biosafety protocols, and work through risk assessments from the perspective of a biosafety officer.

Research Imaging Core: This core will provide theoretical and hands-on training from single cell imaging (confocal microscopy, cytometry, live cell imaging, single cell RNAseq) through to whole body imaging in mice (IVIS) and non-human primates (NHP) (PET/CT). All training will take place within large, fully outfitted BSL3/ABSL3 facilities.

Animal Model Core: This core will implement a training program to introduce all IN-TRAC participants to the regulatory requirements for working with rodents and NHPS. Participants will learn how to develop a robust experimental protocol, how to write an IACUC protocol, and gain hands-on experience in animal handling and experimental procedures.

Clinical Research & Patient Care Core: This core will introduce IN-TRAC participants to TB patient care at the only free-standing TB hospital in the US, the Texas Center of Infectious Diseases. This hospital manages some of the most challenging cases of TB nationally. Additionally, participants will have a clinical research experience at the US-Mexico border, where they will experience TB studies in underserved and under-resourced communities.

Texas Biomedical Research Institute

TO ASSIST PUBLIC AND PRIVATE NONPROFIT INSTITUTIONS AND INDIVIDUALS TO ESTABLISH, EXPAND AND IMPROVE BIOMEDICAL RESEARCH AND RESEARCH TRAINING IN INFECTIOUS DISEASES AND RELATED AREAS, TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS. TO ASSIST PUBLIC, PRIVATE AND COMMERCIAL INSTITUTIONS TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS, TO PROVIDE RESEARCH SERVICES AS REQUIRED BY THE AGENCY FOR PROGRAMS IN INFECTIOUS DISEASES, AND CONTROLLING DISEASE CAUSED BY INFECTIOUS OR PARASITIC AGENTS, ALLERGIC AND IMMUNOLOGIC DISEASES AND RELATED AREAS. PROJECTS RANGE FROM STUDIES OF MICROBIAL PHYSIOLOGY AND ANTIGENIC STRUCTURE TO COLLABORATIVE TRIALS OF EXPERIMENTAL DRUGS AND VACCINES, MECHANISMS OF RESISTANCE TO ANTIBIOTICS AS WELL AS RESEARCH DEALING WITH EPIDEMIOLOGICAL OBSERVATIONS IN HOSPITALIZED PATIENTS OR COMMUNITY POPULATIONS AND PROGRESS IN ALLERGIC AND IMMUNOLOGIC DISEASES. BECAUSE OF THIS DUAL FOCUS, THE PROGRAM ENCOMPASSES BOTH BASIC RESEARCH AND CLINICAL RESEARCH. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM EXPANDS AND IMPROVES PRIVATE SECTOR PARTICIPATION IN BIOMEDICAL RESEARCH. THE SBIR PROGRAM INTENDS TO INCREASE AND FACILITATE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATES AND FOSTERS SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. RESEARCH CAREER DEVELOPMENT AWARDS SUPPORT THE DEVELOPMENT OF SCIENTISTS DURING THE FORMATIVE STAGES OF THEIR CAREERS. INDIVIDUAL NATIONAL RESEARCH SERVICE AWARDS (NRSAS) ARE MADE DIRECTLY TO APPROVE APPLICANTS FOR RESEARCH TRAINING IN SPECIFIED BIOMEDICAL SHORTAGE AREAS. IN ADDITION, INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDS ARE MADE TO ENABLE INSTITUTIONS TO SELECT AND MAKE AWARDS TO INDIVIDUALS TO RECEIVE TRAINING UNDER THE AEGIS OF THEIR INSTITUTIONAL PROGRAM.

93.855 - Allergy and Infectious Diseases Research

National Institute of Allergy and Infectious Diseases (NIAID) [HHS - NIH]

San Antonio, Texas 782275302 United States

Single Zip Code

Tuberculosis Research Advancement Centers (P30 Clinical Trials Not Allowed) (RFA-AI-21-001)

Amendment Since initial award the total obligations have increased 288% from $1,199,368 to $4,649,066.