P30AG072975

Rush Alzheimer's Disease Research Center - Abstract – Overall

The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on the causes, treatments, and prevention of AD/ADRD. While the proposed Rush ADRC is for a new grant, it builds on three decades of work by the current Rush ADCC.

The Rush ADRC has eight cores and one component, which align with the recommendations of the 2017 NIA Strategic Plan, including studies that:

1) Recognize the heterogeneity and multifactorial nature of dementias;
2) Support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness;
3) Employ new research paradigms, e.g., systems biology, human cell modeling;
4) Enable rapid and extensive sharing of data, disease models, specimens, and support open and team science;
5) Develop computational tools and infrastructure for storage, integration, and analysis of large-scale biological and patient-relevant data;
6) Build multidisciplinary translational teams in virtual and real spaces;
7) Develop new pre-competitive public-private partnerships;
8) Change academic, publishing, and funding incentives to promote collaborative, transparent, and reproducible research; and
9) Engage patients, caregivers, and citizens as direct partners in research.

The Administrative Core will provide scientific leadership to the Rush ADRC as a whole. The Religious Orders Study (ROS) Core will recruit and conduct annual evaluations of Catholic clergy without dementia who agree to organ donation. The Clinical and Latino Cores will collect data harmonized with on Blacks and Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate, and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach, Recruitment, and Engagement Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical, ROS, and Latino Cores, and other NIA funded initiatives. The Biomarker/Neuroimaging Core will process neuroimaging generated with other funds from all three cores and affiliated studies, and document neuroimaging and biofluid biomarker data. The New Research and Education Component will provide structured mentoring of students and faculty at all levels. The Data Management and Statistical Core will provide the infrastructure that allows all other cores and the REC to be maximally successful and impactful and will provide statistical support to users of ADRC resources, especially junior investigators and trainees.

Rush University Medical Center

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Illinois United States

State-Wide

Alzheimers Disease Research Centers (P30 Clinical Trial Not Allowed) (RFA-AG-21-019)

Amendment Since initial award the total obligations have increased 298% from $3,127,708 to $12,447,211.