P30AG067988

Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional) - Project Summary

Overall, this proposal seeks to establish the Claude D. Pepper Older Americans Independence Center at UCONN (UCONN OAIC) with the overarching goal of developing clinical strategies for enhancing function and independence in older adults that are more precise, personalized, and effective.

Our focus on precision gerontology has emerged through the collective experiences and insights of our multidisciplinary team of accomplished investigators in the UCONN Center on Aging – all united by a shared commitment to improving the lives of older adults through research, education, and clinical care.

Our emphasis on precision gerontology has been guided by three principles:

1. A growing heterogeneity or variability over time among individuals involving all aspects of aging that therefore necessitates a multidisciplinary team-based approach to aging research.
2. Increased heterogeneity or variability with aging in older adults' responses to treatment, highlighting the need for better targeting.
3. Recognition of a need to incorporate these considerations into the design and testing of novel geroscience-guided therapies.

These objectives will be achieved by establishing a UCONN OAIC through the coordinated activities of a Leadership and Administration Core (LAC), Recruitment and Community Engagement Core (RC1), Data Resource Core (RC2), Biomarker and Preclinical Research Core (RC3), Pilot and Exploratory Studies Core (PESC), and Research Education Component (REC).

We will seek to address these goals through the following aims:

AIM 1: To develop and refine new approaches to the study and clinical translation of precision gerontology.

AIM 2: To develop and evaluate new research methods, techniques, and collaborative approaches required to advance the goals of precision gerontology.

AIM 3: To identify, develop, and learn from experiences of the next generation of researchers poised to become leaders in geriatrics research related to the UCONN OAIC focus.

AIM 4: To select and support innovative pilot studies that show promise in helping to guide the design, funding, and completion of more definitive future research studies related to the UCONN OAIC focus.

University Of Connecticut Health Center

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Farmington, Connecticut 06032 United States

Single Zip Code

Claude D. Pepper Older Americans Independence Centers (P30 Clinical Trial Optional) (RFA-AG-21-024)

Amendment Since initial award the total obligations have increased 363% from $1,484,144 to $6,865,564.