P20GM144269

Kansas Center for Metabolism and Obesity Research (KC-MORE) - Center Overall: Project Summary

This COBRE proposal seeks to establish the Kansas Center for Metabolism and Obesity Research (KC-MORE), which will unify investigators from multiple departments and research centers at the University of Kansas Medical Center. The focus of this center will be on research related to the pathology of obesity, metabolic dysfunction, and obesity-related diseases.

Obesity is a critical problem that is harming the health of people in Kansas as well as the entire U.S. New research-driven solutions and therapies are needed to prevent and treat obesity, investigate metabolic signatures that underlie obesity, and examine mechanisms by which obesity initiates chronic disease.

The KC-MORE will serve to merge these areas of focus by:

1. Creating a shared intellectual home for obesity-related researchers through a common educational and seminar program.
2. Providing funding and mentorship for early stage obesity-related investigators to establish independent research careers.
3. Establishing scientific cores to facilitate translational research of both early stage and established investigators.
4. Partnering with departments to jointly recruit new investigators to KUMC focused on themes of the KC-MORE.

This central role in leading and coordinating obesity research and incentivizing future resources and recruitment will allow KUMC to synergize efforts and form multi-disciplinary collaborations on obesity, metabolism, and obesity-induced disease research in ways that would not occur without COBRE funding.

The KC-MORE will be led by two multi-PIs, Drs. Steven Weinman and John Thyfault, and a renowned senior investigator, Dr. Joseph Donnelly, who will serve as chair of the steering committee and lead human energy balance research. These leaders have multi-disciplinary but complimentary expertise in basic, clinical, and translational research.

Phase 1 of the center will support the development of four research project leaders (RPLs) with studies on neural control of energy balance, clinical-based approaches to weight loss in rural communities, and basic mechanisms of obesity-related fatty liver disease and hypertension. KC-MORE will also administer a pilot awards program to develop additional KC-MORE researchers.

The KC-MORE will lead three new scientific cores that provide a foundation for translational research capabilities: the Metabolism (MET) Core, the Cells, Tissues, Bioanalysis and Bioinformatics (CTBB) Core, and the Human Energy Balance (HEB) Core. These cores will support infrastructure and methodologies for the research project leaders, the pilot award recipients, and a large pool of established obesity-related researchers on campus.

A critical goal of Phase 1 of the KC-MORE COBRE will be to help RPLs develop independent, R01-funded research programs. Overall, the establishment of the KC-MORE will serve to develop a translational and multi-disciplinary obesity research program that will have a significant future impact by reducing the burden of obesity-related disease conditions.

University Of Kansas Medical Center Research Institute

THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES (NIGMS) SUPPORTS BASIC RESEARCH THAT INCREASES OUR UNDERSTANDING OF BIOLOGICAL PROCESSES AND LAYS THE FOUNDATION FOR ADVANCES IN DISEASE DIAGNOSIS, TREATMENT, AND PREVENTION. NIGMS ALSO SUPPORTS RESEARCH IN SPECIFIC CLINICAL AREAS THAT AFFECT MULTIPLE ORGAN SYSTEMS: ANESTHESIOLOGY AND PERI-OPERATIVE PAIN, CLINICAL PHARMACOLOGY ?COMMON TO MULTIPLE DRUGS AND TREATMENTS, AND INJURY, CRITICAL ILLNESS, SEPSIS, AND WOUND HEALING.? NIGMS-FUNDED SCIENTISTS INVESTIGATE HOW LIVING SYSTEMS WORK AT A RANGE OF LEVELSFROM MOLECULES AND CELLS TO TISSUES AND ORGANSIN RESEARCH ORGANISMS, HUMANS, AND POPULATIONS. ADDITIONALLY, TO ENSURE THE VITALITY AND CONTINUED PRODUCTIVITY OF THE RESEARCH ENTERPRISE, NIGMS PROVIDES LEADERSHIP IN SUPPORTING THE TRAINING OF THE NEXT GENERATION OF SCIENTISTS, ENHANCING THE DIVERSITY OF THE SCIENTIFIC WORKFORCE, AND DEVELOPING RESEARCH CAPACITY THROUGHOUT THE COUNTRY.

93.859 - Biomedical Research and Research Training

National Institute of General Medical Sciences (NIGMS) [HHS - NIH]

Kansas City, Kansas 66160 United States

Single Zip Code

Centers of Biomedical Research Excellence (COBRE) Phase 1 (P20 - Clinical Trial Optional) (PAR-19-313)

Amendment Since initial award the total obligations have increased 291% from $2,615,402 to $10,233,525.