P20GM139759

Indigenous Trauma & Resilience Research Center - Overall Project Abstract

Indigenous populations experience significant trauma-related health disparities, including addiction, post-traumatic stress disorder, chronic diseases, infant mortality, and suicide. Many of these disparities are worse for American Indians (AIs) in the Dakotas. AI communities also contend with historical and intergenerational trauma from decades of traumatic losses and forced assimilation. Hence, we will establish the Indigenous Trauma & Resilience Research Center at UND to address the health impact of unresolved trauma and the protective factors of cultural connectedness and resilience.

The center will consist of three interrelated research projects—each led by an early career investigator and assisted by senior scientist mentors.

Objectives:

1. Establish a nationally-recognized and acclaimed Indigenous Trauma & Resilience Research Center at UND with a goal to improve AI health and well-being.

2. Provide support and mentoring to the project leaders to enable future success in obtaining R01 funding.

3. Establish administrative, community engagement & outreach, and human subjects cores that will support the center and provide services to strengthen research capacity to address Indigenous health.

Methods:

Three research projects include:

(1) Historical trauma and resilience as a biological state and its association with the effects of the traditional Indigenous food chokeberry.

(2) Impact of boarding school attendance on perceived stress, allostatic load, and resilience.

(3) Stress and health in American Indian pregnancies.

We will leverage existing assets at UND, including several Institutional Development Award (IDEA) programs. Mentoring will be provided to support the project leaders through an administrative core consisting of the program director/principal investigator (PD/PI), internal and external advisory committees, and a group of high-level scientific project mentors.

Each project leader will use community-based, participatory research principles and will complete the tribal community engagement training module that was developed by the PD/PI. A community engagement & outreach core will be led by Dr. Melanie Nadeau of the Turtle Mountain Band of Chippewa Indians from ND.

Cultural considerations for human subjects research and collection of biological samples will be supported by a human subjects core that will provide technical assistance regarding research compliance and addressing cultural norms.

Significant opportunities exist for meta-scholarship in which COBRE stakeholders will publish best and promising practices to support community-engaged human subjects research with Indigenous populations.

The center will be sustainable and competitive for numerous other grant programs, including Research Project Grants (R01) and related funding.

University Of North Dakota

THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES (NIGMS) SUPPORTS BASIC RESEARCH THAT INCREASES OUR UNDERSTANDING OF BIOLOGICAL PROCESSES AND LAYS THE FOUNDATION FOR ADVANCES IN DISEASE DIAGNOSIS, TREATMENT, AND PREVENTION. NIGMS ALSO SUPPORTS RESEARCH IN SPECIFIC CLINICAL AREAS THAT AFFECT MULTIPLE ORGAN SYSTEMS: ANESTHESIOLOGY AND PERI-OPERATIVE PAIN, CLINICAL PHARMACOLOGY ?COMMON TO MULTIPLE DRUGS AND TREATMENTS, AND INJURY, CRITICAL ILLNESS, SEPSIS, AND WOUND HEALING.? NIGMS-FUNDED SCIENTISTS INVESTIGATE HOW LIVING SYSTEMS WORK AT A RANGE OF LEVELSFROM MOLECULES AND CELLS TO TISSUES AND ORGANSIN RESEARCH ORGANISMS, HUMANS, AND POPULATIONS. ADDITIONALLY, TO ENSURE THE VITALITY AND CONTINUED PRODUCTIVITY OF THE RESEARCH ENTERPRISE, NIGMS PROVIDES LEADERSHIP IN SUPPORTING THE TRAINING OF THE NEXT GENERATION OF SCIENTISTS, ENHANCING THE DIVERSITY OF THE SCIENTIFIC WORKFORCE, AND DEVELOPING RESEARCH CAPACITY THROUGHOUT THE COUNTRY.

93.859 - Biomedical Research and Research Training

National Institute of General Medical Sciences (NIGMS) [HHS - NIH]

Grand Forks, North Dakota 582027306 United States

Single Zip Code

Centers of Biomedical Research Excellence (COBRE) Phase 1 (P20 - Clinical Trial Optional) (PAR-19-313)

Amendment Since initial award the total obligations have increased 293% from $2,115,001 to $8,302,006.