P01AI179570
Project Grant
Overview
Grant Description
Predictors and determinants of pediatric immunity (PEDS) - the unique characteristics of the human immune response in early life are critically important and yet remain poorly understood.
Our overarching hypothesis is that the pediatric immune system is not just a naïve adult immune system but is fundamentally different.
The challenges associated with pediatric studies, including small sample volumes and rare diseases, have been barriers to meaningful progress in the field, and there are numerous basic questions that remain unaddressed.
By taking a synergistic multi-pronged approach, we aim to better understand the unique biology of pediatric immunity and its implications for normal immune function as well as a variety of disease states.
The central hypothesis addressed in this program project is that genetics, developmental stage, and immune challenges shape the trajectories of antigen-specific and -agnostic homeostatic set points that determine future immune response quality and quantity.
Our three projects, with support of our four cores, will synergize in addressing the following overarching and interconnected scientific aims.
Aim 1: Uncover genetic and neonatal determinants of temporally ultra-stable, individualistic immune states established at infancy.
Aim 2: Determine dynamic immune parameters remodeled throughout the pediatric age range by immune exposures, developmental variables, and genetics.
Aim 3: Elucidate how baseline immune states predict and determine responses to immune challenges in an age-dependent manner in childhood.
Our program will leverage multiple human subject cohorts that will offer important insights with broad relevance.
Together, this work will enable us to construct a ‘growth chart’ of sorts for the pediatric immune system that will better enable identification and assessment of genetic, environmental, and developmental conditions that deviate immune trajectories into unhealthy ranges.
Our overarching hypothesis is that the pediatric immune system is not just a naïve adult immune system but is fundamentally different.
The challenges associated with pediatric studies, including small sample volumes and rare diseases, have been barriers to meaningful progress in the field, and there are numerous basic questions that remain unaddressed.
By taking a synergistic multi-pronged approach, we aim to better understand the unique biology of pediatric immunity and its implications for normal immune function as well as a variety of disease states.
The central hypothesis addressed in this program project is that genetics, developmental stage, and immune challenges shape the trajectories of antigen-specific and -agnostic homeostatic set points that determine future immune response quality and quantity.
Our three projects, with support of our four cores, will synergize in addressing the following overarching and interconnected scientific aims.
Aim 1: Uncover genetic and neonatal determinants of temporally ultra-stable, individualistic immune states established at infancy.
Aim 2: Determine dynamic immune parameters remodeled throughout the pediatric age range by immune exposures, developmental variables, and genetics.
Aim 3: Elucidate how baseline immune states predict and determine responses to immune challenges in an age-dependent manner in childhood.
Our program will leverage multiple human subject cohorts that will offer important insights with broad relevance.
Together, this work will enable us to construct a ‘growth chart’ of sorts for the pediatric immune system that will better enable identification and assessment of genetic, environmental, and developmental conditions that deviate immune trajectories into unhealthy ranges.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
New Haven,
Connecticut
065191612
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 121% from $2,654,646 to $5,870,097.
Yale Univ was awarded
Pediatric Immunity: Understanding Unique Biological Factors Implications
Project Grant P01AI179570
worth $5,870,097
from the National Institute of Allergy and Infectious Diseases in July 2025 with work to be completed primarily in New Haven Connecticut United States.
The grant
has a duration of 4 years 10 months and
was awarded through assistance program 93.855 Allergy and Infectious Diseases Research.
The Project Grant was awarded through grant opportunity NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/22/26
Period of Performance
7/23/25
Start Date
5/31/30
End Date
Funding Split
$5.9M
Federal Obligation
$0.0
Non-Federal Obligation
$5.9M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for P01AI179570
Transaction History
Modifications to P01AI179570
Additional Detail
Award ID FAIN
P01AI179570
SAI Number
P01AI179570-988162253
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NM00 NIH National Institute of Allergy and Infectious Diseases
Funding Office
75NM00 NIH National Institute of Allergy and Infectious Diseases
Awardee UEI
FL6GV84CKN57
Awardee CAGE
4B992
Performance District
CT-03
Senators
Richard Blumenthal
Christopher Murphy
Christopher Murphy
Modified: 6/22/26