K43TW012641
Project Grant
Overview
Grant Description
Community-Based Medication Adherence Support for Older Adults Living with HIV and Hypertension (CBA Intervention) - Project Summary
Due to the increasing availability of ART, people living with HIV (PLWH) are surviving longer and achieving life expectancies similar to the general population. While this is a great achievement, noncommunicable diseases such as cardiovascular disease (CVD) now account for a significant proportion of the morbidity and mortality in PLWH.
Poor HTN medication adherence is associated with uncontrolled blood pressure (BP) and increased risk of CVD events such as myocardial infarction. Despite this risk, medication adherence research in PLWH is primarily focused on ART with limited focus on adherence to other chronic comorbidities.
Medication adherence is a complex health behavior that is driven by confluence of factors that operate at micro- and macro-levels. As people age with HIV, their needs increase beyond solely managing HIV medication adherence, to include management of other conditions and their medications.
Increased pill burden faced by older adults living with HIV (OALWH) with HTN, coupled with decline in cognitive function, cost of transportation to the facility to get medication refill and lack of social support worsen adherence. Differences in access particularly in LMICs, where ART is free and HTN medication are not, wider adverse effect profiles of HTN drugs, and lack of polypills in HTN care could also contribute to non-adherence.
Adherence support for OALWH with HTN targeted at these factors may help improve medication adherence and reduce CVD events.
In this K43 application, the applicant proposes a training plan that will enable her gain skills and expertise in human-centered design approach, implementation science theories, models and frameworks, and economic evaluation of health interventions. Her research will addressing the following specific aims:
- Co-design a novel CHV-led model for medication adherence support (CBA Intervention) for OALWH using a human-centered design approach (Aim 1).
- Conduct a pilot of CBA Intervention and evaluate its feasibility (Aim 2).
- Conduct costing and budget impact analysis of CBA Intervention (Aim 3).
The proposed K43 career development activities including the outcome of the proposed research will culminate in my transition to an independent researcher (R01-funded), contributing in the field of HIV and aging.
Due to the increasing availability of ART, people living with HIV (PLWH) are surviving longer and achieving life expectancies similar to the general population. While this is a great achievement, noncommunicable diseases such as cardiovascular disease (CVD) now account for a significant proportion of the morbidity and mortality in PLWH.
Poor HTN medication adherence is associated with uncontrolled blood pressure (BP) and increased risk of CVD events such as myocardial infarction. Despite this risk, medication adherence research in PLWH is primarily focused on ART with limited focus on adherence to other chronic comorbidities.
Medication adherence is a complex health behavior that is driven by confluence of factors that operate at micro- and macro-levels. As people age with HIV, their needs increase beyond solely managing HIV medication adherence, to include management of other conditions and their medications.
Increased pill burden faced by older adults living with HIV (OALWH) with HTN, coupled with decline in cognitive function, cost of transportation to the facility to get medication refill and lack of social support worsen adherence. Differences in access particularly in LMICs, where ART is free and HTN medication are not, wider adverse effect profiles of HTN drugs, and lack of polypills in HTN care could also contribute to non-adherence.
Adherence support for OALWH with HTN targeted at these factors may help improve medication adherence and reduce CVD events.
In this K43 application, the applicant proposes a training plan that will enable her gain skills and expertise in human-centered design approach, implementation science theories, models and frameworks, and economic evaluation of health interventions. Her research will addressing the following specific aims:
- Co-design a novel CHV-led model for medication adherence support (CBA Intervention) for OALWH using a human-centered design approach (Aim 1).
- Conduct a pilot of CBA Intervention and evaluate its feasibility (Aim 2).
- Conduct costing and budget impact analysis of CBA Intervention (Aim 3).
The proposed K43 career development activities including the outcome of the proposed research will culminate in my transition to an independent researcher (R01-funded), contributing in the field of HIV and aging.
Funding Goals
THE JOHN E. FOGARTY INTERNATIONAL CENTER (FIC) SUPPORTS RESEARCH AND RESEARCH TRAINING TO REDUCE DISPARITIES IN GLOBAL HEALTH AND TO FOSTER PARTNERSHIPS BETWEEN U.S. SCIENTISTS AND THEIR COUNTERPARTS ABROAD. FIC SUPPORTS BASIC BIOLOGICAL, BEHAVIORAL, AND SOCIAL SCIENCE RESEARCH, AS WELL AS RELATED RESEARCH TRAINING AND CAREER DEVELOPMENT. THE RESEARCH PORTFOLIO IS DIVIDED INTO SEVERAL PROGRAMS THAT SUPPORT A WIDE VARIETY OF FUNDING MECHANISMS TO MEET PROGRAMMATIC OBJECTIVES.
Grant Program (CFDA)
Awarding Agency
Funding Agency
Place of Performance
Kenya
Geographic Scope
Foreign
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 34020200% from $1 to $340,203.
MOI University College Of Health Sciences was awarded
Medication Adherence Support Older Adults with HIV Hypertension (CBA Intervention)
Project Grant K43TW012641
worth $340,203
from National Heart Lung and Blood Institute in July 2023 with work to be completed primarily in Kenya.
The grant
has a duration of 4 years 9 months and
was awarded through assistance program 93.837 Cardiovascular Diseases Research.
The Project Grant was awarded through grant opportunity Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 5/5/25
Period of Performance
7/15/23
Start Date
4/30/28
End Date
Funding Split
$340.2K
Federal Obligation
$0.0
Non-Federal Obligation
$340.2K
Total Obligated
Activity Timeline
Transaction History
Modifications to K43TW012641
Additional Detail
Award ID FAIN
K43TW012641
SAI Number
K43TW012641-3721521016
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Non-Domestic (Non-U.S.) Entity
Awarding Office
75NF00 NIH Fogarty International Center
Funding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Awardee UEI
SRYVEXCCSNK3
Awardee CAGE
SCJ12
Performance District
Not Applicable
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Heart, Lung, and Blood Institute, National Institutes of Health, Health and Human Services (075-0872) | Health research and training | Grants, subsidies, and contributions (41.0) | $113,400 | 100% |
Modified: 5/5/25