K43TW012586
Project Grant
Overview
Grant Description
Delineating the Kidney Brain Axis in Children with Severe Malaria (KID-BRAIN) - Project Summary/ Abstract
The overall goal of this career award is to build Dr. Batte into an independently funded physician scientist improving survival of children with acute kidney injury (AKI) and identify interventions that will enable children to thrive. Dr. Batte will delineate mechanisms of kidney-related brain injury in children with severe malaria.
Dr. Batte is a lecturer and a pediatric nephrologist at Makerere University College of Health Sciences. From his past research work, he has established evidence-based approaches to AKI diagnosis and phenotypic characterization. He has explored the utility of point-of-care tests in evaluating AKI and has mechanistically compared severe malaria AKI and non-malaria febrile illnesses related AKI, demonstrating differences in endothelial activation and immune activation. He has also evaluated brain injury and neurological outcomes of children with AKI following acute malnutrition and sickle cell anemia. He has published an invited review highlighting challenges in the diagnosis and management of AKI in children and outlined priorities for future research, which included detailed neuro-developmental assessments following AKI in children with severe malaria.
Dr. Batte will use the 75% protected time for the next 5 years working with his mentors to understand how acute changes in brain-kidney crosstalk translate to long-term injury and to identify modifiable pathways amenable to intervention to promote adaptive kidney and brain recovery following severe malaria. Dr. Batte has developed an educational plan that builds on his past training and addresses research training gaps, that once filled will provide the basis to propel him into an independent research career. This K43 will be structured around specialized training in neurobehavioral evaluation along with biomarker testing and interpretation. It will help Dr. Batte to achieve his objectives which are to; (1) determine the extent that AKI phenotypes are associated with biosignatures of brain injury and recovery (2) establish the extent that AKI and AKI phenotypes are associated with cerebral edema (3) define the association between neurobehavioral outcomes, brain injury biomarkers, and AKI phenotypes.
Dr. Batte will attain a number of skill-sets in kidney and brain biomarker testing and interpretation, skills in brain imaging interpretation, data analysis, and conduct of longitudinal studies, and neurobehavioral evaluation of children. It is expected that at completion of this award, with the developed expertise and data generated, he will elucidate modifiable pathways of kidney-brain crosstalk in severe malaria, setting the stage for an R01 application and a platform for future intervention studies to prevent injury and promote brain and kidney recovery following severe malaria.
The overall goal of this career award is to build Dr. Batte into an independently funded physician scientist improving survival of children with acute kidney injury (AKI) and identify interventions that will enable children to thrive. Dr. Batte will delineate mechanisms of kidney-related brain injury in children with severe malaria.
Dr. Batte is a lecturer and a pediatric nephrologist at Makerere University College of Health Sciences. From his past research work, he has established evidence-based approaches to AKI diagnosis and phenotypic characterization. He has explored the utility of point-of-care tests in evaluating AKI and has mechanistically compared severe malaria AKI and non-malaria febrile illnesses related AKI, demonstrating differences in endothelial activation and immune activation. He has also evaluated brain injury and neurological outcomes of children with AKI following acute malnutrition and sickle cell anemia. He has published an invited review highlighting challenges in the diagnosis and management of AKI in children and outlined priorities for future research, which included detailed neuro-developmental assessments following AKI in children with severe malaria.
Dr. Batte will use the 75% protected time for the next 5 years working with his mentors to understand how acute changes in brain-kidney crosstalk translate to long-term injury and to identify modifiable pathways amenable to intervention to promote adaptive kidney and brain recovery following severe malaria. Dr. Batte has developed an educational plan that builds on his past training and addresses research training gaps, that once filled will provide the basis to propel him into an independent research career. This K43 will be structured around specialized training in neurobehavioral evaluation along with biomarker testing and interpretation. It will help Dr. Batte to achieve his objectives which are to; (1) determine the extent that AKI phenotypes are associated with biosignatures of brain injury and recovery (2) establish the extent that AKI and AKI phenotypes are associated with cerebral edema (3) define the association between neurobehavioral outcomes, brain injury biomarkers, and AKI phenotypes.
Dr. Batte will attain a number of skill-sets in kidney and brain biomarker testing and interpretation, skills in brain imaging interpretation, data analysis, and conduct of longitudinal studies, and neurobehavioral evaluation of children. It is expected that at completion of this award, with the developed expertise and data generated, he will elucidate modifiable pathways of kidney-brain crosstalk in severe malaria, setting the stage for an R01 application and a platform for future intervention studies to prevent injury and promote brain and kidney recovery following severe malaria.
Funding Goals
THE JOHN E. FOGARTY INTERNATIONAL CENTER (FIC) SUPPORTS RESEARCH AND RESEARCH TRAINING TO REDUCE DISPARITIES IN GLOBAL HEALTH AND TO FOSTER PARTNERSHIPS BETWEEN U.S. SCIENTISTS AND THEIR COUNTERPARTS ABROAD. FIC SUPPORTS BASIC BIOLOGICAL, BEHAVIORAL, AND SOCIAL SCIENCE RESEARCH, AS WELL AS RELATED RESEARCH TRAINING AND CAREER DEVELOPMENT. THE RESEARCH PORTFOLIO IS DIVIDED INTO SEVERAL PROGRAMS THAT SUPPORT A WIDE VARIETY OF FUNDING MECHANISMS TO MEET PROGRAMMATIC OBJECTIVES.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Uganda
Geographic Scope
Foreign
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 200% from $96,471 to $289,502.
Makerere University College Of Health Sciences was awarded
Kid-Brain: Delineating Kidney-Brain Axis in Severe Malaria
Project Grant K43TW012586
worth $289,502
from Fogarty International Center in August 2023 with work to be completed primarily in Uganda.
The grant
has a duration of 4 years 8 months and
was awarded through assistance program 93.989 International Research and Research Training.
The Project Grant was awarded through grant opportunity Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 5/5/25
Period of Performance
8/20/23
Start Date
4/30/28
End Date
Funding Split
$289.5K
Federal Obligation
$0.0
Non-Federal Obligation
$289.5K
Total Obligated
Activity Timeline
Transaction History
Modifications to K43TW012586
Additional Detail
Award ID FAIN
K43TW012586
SAI Number
K43TW012586-1210412915
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NF00 NIH Fogarty International Center
Funding Office
75NF00 NIH Fogarty International Center
Awardee UEI
QSXBGHKN8KV6
Awardee CAGE
STR11
Performance District
Not Applicable
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| John E. Fogarty International Center, National Institutes of Health, Health and Human Services (075-0819) | Health research and training | Grants, subsidies, and contributions (41.0) | $96,471 | 100% |
Modified: 5/5/25