K43TW011963
Project Grant
Overview
Grant Description
Leveraging existing HIV differentiated service delivery models to screen and treat hypertension in Ugandan persons living with HIV for dual control - Project Summary/Abstract.
The overall goal of the proposed Emerging Global Leader Award is to support Dr. Martin Muddu’s research training to develop as an independent implementation science investigator in HIV and hypertension. Dr. Muddu is a research scientist at the Infectious Diseases Research Collaboration (IDRC) in Kampala, Uganda.
He proposes to conduct an implementation science study to integrate HTN screening and treatment into community-based, patient-centered models of HIV care known as “Differentiated Service Delivery.” Accomplishing the proposed study in this application will facilitate his training goals to: 1) gain mastery of mixed methods implementation science research; 2) acquire expertise in design and analysis of quasi-experimental studies; and 3) develop skills in leadership, grant and manuscript writing, and mentoring of junior investigators.
This proposal builds on the skills he already has in HIV and hypertension clinical medicine and methods of observational studies. He will leverage an interdisciplinary team of mentors and advisors with expertise in his area of study to become a productive independent researcher.
Hypertension affects nearly one-third of Ugandan PLHIV, a large proportion of whom are undiagnosed and untreated. The World Health Organization HEARTS package is an evidence-based strategy for HTN management, which we propose to adapt, integrate, and implement into community HIV differentiated service delivery models using rigorous implementation science methods. This will form the integrated hypertension-HIV differentiated service delivery model.
We will then evaluate the implementation and effectiveness of the integrated hypertension-HIV differentiated service delivery model regarding hypertension control in PLHIV. If implemented, this project will generate evidence to inform guidelines for integration of HTN management into patient-centered community models of HIV care in Uganda and beyond.
The overall goal of the proposed Emerging Global Leader Award is to support Dr. Martin Muddu’s research training to develop as an independent implementation science investigator in HIV and hypertension. Dr. Muddu is a research scientist at the Infectious Diseases Research Collaboration (IDRC) in Kampala, Uganda.
He proposes to conduct an implementation science study to integrate HTN screening and treatment into community-based, patient-centered models of HIV care known as “Differentiated Service Delivery.” Accomplishing the proposed study in this application will facilitate his training goals to: 1) gain mastery of mixed methods implementation science research; 2) acquire expertise in design and analysis of quasi-experimental studies; and 3) develop skills in leadership, grant and manuscript writing, and mentoring of junior investigators.
This proposal builds on the skills he already has in HIV and hypertension clinical medicine and methods of observational studies. He will leverage an interdisciplinary team of mentors and advisors with expertise in his area of study to become a productive independent researcher.
Hypertension affects nearly one-third of Ugandan PLHIV, a large proportion of whom are undiagnosed and untreated. The World Health Organization HEARTS package is an evidence-based strategy for HTN management, which we propose to adapt, integrate, and implement into community HIV differentiated service delivery models using rigorous implementation science methods. This will form the integrated hypertension-HIV differentiated service delivery model.
We will then evaluate the implementation and effectiveness of the integrated hypertension-HIV differentiated service delivery model regarding hypertension control in PLHIV. If implemented, this project will generate evidence to inform guidelines for integration of HTN management into patient-centered community models of HIV care in Uganda and beyond.
Funding Goals
THE JOHN E. FOGARTY INTERNATIONAL CENTER (FIC) SUPPORTS RESEARCH AND RESEARCH TRAINING TO REDUCE DISPARITIES IN GLOBAL HEALTH AND TO FOSTER PARTNERSHIPS BETWEEN U.S. SCIENTISTS AND THEIR COUNTERPARTS ABROAD. FIC SUPPORTS BASIC BIOLOGICAL, BEHAVIORAL, AND SOCIAL SCIENCE RESEARCH, AS WELL AS RELATED RESEARCH TRAINING AND CAREER DEVELOPMENT. THE RESEARCH PORTFOLIO IS DIVIDED INTO SEVERAL PROGRAMS THAT SUPPORT A WIDE VARIETY OF FUNDING MECHANISMS TO MEET PROGRAMMATIC OBJECTIVES.
Grant Program (CFDA)
Awarding Agency
Funding Agency
Place of Performance
Uganda
Geographic Scope
Foreign
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 488% from $113,400 to $667,003.
Infectious Diseases Research Collaboration was awarded
HIV Hypertension Integration Project in Uganda
Project Grant K43TW011963
worth $667,003
from National Heart Lung and Blood Institute in September 2021 with work to be completed primarily in Uganda.
The grant
has a duration of 4 years 8 months and
was awarded through assistance program 93.837 Cardiovascular Diseases Research.
The Project Grant was awarded through grant opportunity Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/5/25
Period of Performance
9/20/21
Start Date
5/31/26
End Date
Funding Split
$667.0K
Federal Obligation
$0.0
Non-Federal Obligation
$667.0K
Total Obligated
Activity Timeline
Transaction History
Modifications to K43TW011963
Additional Detail
Award ID FAIN
K43TW011963
SAI Number
K43TW011963-3833482922
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Nonprofit Without 501(c)(3) IRS Status (Other Than An Institution Of Higher Education)
Awarding Office
75NF00 NIH Fogarty International Center
Funding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Awardee UEI
KEWUKWPQSYH9
Awardee CAGE
SKU12
Performance District
Not Applicable
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Heart, Lung, and Blood Institute, National Institutes of Health, Health and Human Services (075-0872) | Health research and training | Grants, subsidies, and contributions (41.0) | $226,800 | 69% |
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $100,000 | 31% |
Modified: 6/5/25