K43TW011929

Self-management among adolescents living with HIV in Uganda - project summary/abstract

There are over 73,000 adolescents living with HIV (ALHIV) in Uganda, constituting 4% of the worldwide population of ALHIV. HIV remains a leading cause of death among adolescents, despite widespread availability of antiretroviral medication. Generally, ALHIV have poor outcomes with higher rates of loss to follow up compared with other age groups. Mortality rates and loss to follow up are highest during the transition period.

Transition success may be maximized for ALHIV who are better prepared to negotiate care in adult HIV clinic settings. This preparation can include skills training to improve self-efficacy, resilience, and education to address lack of HIV knowledge, both of which are predictive of better outcomes following transition. Provision of psychosocial support and preparatory information to navigate adult HIV care services have also been associated with successful transition.

The overall goal of the proposed K43 application is to complement my clinical background in psychiatry with advanced coursework and focused mentoring in behavioral science and development and testing of behavioral interventions to improve transition in care. This training will enable me to achieve my scientific objective: to develop and test a self-management intervention for ALHIV transitioning to adult HIV care.

This application proposes to develop a self-management intervention for ALHIV transitioning to adult HIV care and test the impacts of the intervention on HIV outcomes. Conducting the proposed studies in this application will complement my prior training in psychiatry while filling key gaps in three areas: (a) behavioral science theories and their application to behavioral interventions, (b) adaptation and design of behavioral interventions, and (c) testing of behavioral interventions through randomized trials.

To fill these gaps, I will conduct qualitative research to elaborate a conceptual framework of the barriers faced by ALHIV transitioning to adult HIV care in Uganda (Aim 1), develop a self-management intervention that will enable ALHIV to successfully transition to adult HIV care (Aim 2), and assess feasibility, acceptability, and preliminary effects of the self-management intervention on HIV outcomes for ALHIV transitioning to adult HIV care (Aim 3).

This study will be the first to develop a self-management intervention targeting the critical transition period from pediatric to adult HIV care in sub-Saharan Africa and the first to use a randomized design to test the effect of a self-management intervention on health outcomes among ALHIV in Uganda who are transitioning to adult HIV care. These findings will have significant public health impact by optimizing health outcomes for a key population in the global HIV epidemic.

The proposed research will serve as the basis for a competitive R01 grant proposal, submitted in year 4, to conduct a fully-powered, randomized controlled trial to evaluate the effectiveness of a behavioral intervention to improve retention in care and viral suppression among ALHIV in Uganda who are navigating the critical period of transition to adult HIV care.

Mbarara University Of Science And Technology

THE JOHN E. FOGARTY INTERNATIONAL CENTER (FIC) SUPPORTS RESEARCH AND RESEARCH TRAINING TO REDUCE DISPARITIES IN GLOBAL HEALTH AND TO FOSTER PARTNERSHIPS BETWEEN U.S. SCIENTISTS AND THEIR COUNTERPARTS ABROAD. FIC SUPPORTS BASIC BIOLOGICAL, BEHAVIORAL, AND SOCIAL SCIENCE RESEARCH, AS WELL AS RELATED RESEARCH TRAINING AND CAREER DEVELOPMENT. THE RESEARCH PORTFOLIO IS DIVIDED INTO SEVERAL PROGRAMS THAT SUPPORT A WIDE VARIETY OF FUNDING MECHANISMS TO MEET PROGRAMMATIC OBJECTIVES.

93.989 - International Research and Research Training

Fogarty International Center (FIC) [HHS - NIH]

Uganda

Foreign

Emerging Global Leader Award (K43 Independent Clinical Trial Required) (PAR-19-051)

Amendment Since initial award the total obligations have increased 396% from $108,335 to $537,809.