D43TW013008

MALI-NORTHWESTERN UNIVERSITY BREAST CANCER PREVENTION RESEARCH TRAINING PROGRAM (MN-BCP) - TITLE: MALI-NORTHWESTERN UNIVERSITY BREAST CANCER PREVENTION RESEARCH TRAINING PROGRAM (MN-BCP) SUMMARY: WHILE BREAST CANCER IS THE LEADING CAUSE OF CANCER AND DEATH IN WOMEN WORLDWIDE, THERE IS SUBSTANTIAL HETERO- GENEITY IN DISEASE BURDEN BETWEEN HIGH-INCOME - (HICS) AND LOW AND MIDDLE-INCOME COUNTRIES (LMICS).1 IN MANY LMICS, BREAST CANCER INCIDENCE IS RAPIDLY INCREASING, SUGGESTIVE OF THE SO-CALLED “LATE” PHASE EPIDEMIO- LOGICAL TRANSITION TO INCREASED INCIDENCE OF ALL TYPES OF CANCER AND NON-COMMUNICABLE DISEASES, ALTHOUGH ABSO- LUTE RATES ARE STILL LOWER IN LMICS THAN HICS. IN MALI, THE 8TH LARGEST AFRICAN COUNTRY, LOCATED IN WEST AFRICA, BREAST CANCER RECENTLY BECAME THE SECOND MOST FREQUENT AFTER CERVICAL CANCER IN WOMEN. IN ADDITION, BREAST CANCER AFFECTS MALIAN AND AFRICAN WOMEN A DECADE EARLIER (MEAN AGE: 27.1 ± 11.7 YEARS) THAN WOMEN IN HICS, AND DISEASE PROGRESSION IS AGGRESSIVE WITH HIGH MORTALITY. IN MALI, THE MAJORITY OF BREAST CANCER CASES ARE DIAG- NOSED AT A LATE STAGE WHEN TREATMENT IS LESS EFFECTIVE, WHICH CONTRIBUTES SIGNIFICANTLY TO HIGH MORTALITY RATES. WE PROPOSE A NEW PROGRAM, MALI-NORTHWESTERN UNIVERSITY BREAST CANCER PREVENTION (MN-BCP) RESEARCH TRAINING PROGRAM WITH THESE SPECIFIC AIMS: AIM 1: TRAIN TWO (2) PHD-LEVEL CANCER EPIDEMIOLOGISTS, ONE (1) MASTER’S-LEVEL MOLECULAR PATHOLOGIST, ONE (1) BIOSTATISTICIAN WITH A FOCUS ON BREAST CANCER PREVENTION; AIM 2: CREATE AN HYBRID MASTER OF SCIENCE IN APPLIED DESIGN AND IMPLEMENTATION SCIENCE IN HEALTHCARE AT USTTB; AIM 3: ENHANCE KNOWLEDGE, SKILLS, AND EXPERTISE IN BREAST CANCER SCREENING, PREVENTION, AND OUT- COMES RESEARCH AMONG EXISTING PUBLIC HEALTH SCIENTISTS, CLINICIANS, AND STAKEHOLDERS THROUGH SHORT- AND ME- DIUM-TERM. THIS NEW MODEL OF TRAINING IS INNOVATIVE AND WILL HAVE SIGNIFICANT IMPLICATIONS FOR ADVANCING PUBLIC HEALTH NOT ONLY IN MALI BUT ACROSS AFRICA AND, POTENTIALLY, FOR MANY OTHER LOW- AND MIDDLE-INCOME NATIONS.

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THE JOHN E. FOGARTY INTERNATIONAL CENTER (FIC) SUPPORTS RESEARCH AND RESEARCH TRAINING TO REDUCE DISPARITIES IN GLOBAL HEALTH AND TO FOSTER PARTNERSHIPS BETWEEN U.S. SCIENTISTS AND THEIR COUNTERPARTS ABROAD. FIC SUPPORTS BASIC BIOLOGICAL, BEHAVIORAL, AND SOCIAL SCIENCE RESEARCH, AS WELL AS RELATED RESEARCH TRAINING AND CAREER DEVELOPMENT. THE RESEARCH PORTFOLIO IS DIVIDED INTO SEVERAL PROGRAMS THAT SUPPORT A WIDE VARIETY OF FUNDING MECHANISMS TO MEET PROGRAMMATIC OBJECTIVES.

93.989 - International Research and Research Training

Fogarty International Center (FIC) [HHS - NIH]

Mali

Foreign

Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43 Clinical Trial Optional) (PAR-22-104)