D25AC00460

LIVER DISEASE CONSTITUTES AN URGENT PUBLIC HEALTH CHALLENGE BECAUSE UNLIKE MOST OTHER DISEASES DEATHS DUE TO LIVER DISEASE ARE RAPIDLY RISING. THIS INCREASE IS ADDING TO AN ALREADY ENORMOUS HEALTH BURDEN IN WHICH LIVER DISEASE CAUSES OVER 2 MILLION DEATHS EACH YEAR. AS JUST ONE EXAMPLE OF THE CHALLENGE OF LIVER DISEASE ACUTE LIVER FAILURE (ALF) LEADS TO LOST LIVER FUNCTION COAGULOPATHY ENCEPHALOPATHY AND HIGH PATIENT MORTALITY OF 40% TO 90%. IN ADDITION PATIENTS WITH LIVER DISEASE AWAITING TRANSPLANT FACE SEVERE SHORTAGES AND A LIFETIME OF SUFFERING UNDER IMMUNOSUPPRESSION. TO ADDRESS THIS MAJOR HEALTH CHALLENGE OUR LIVER IMMUNOCOMPETENT VOLUMETRIC ENGINEERING (LIVE) PROPOSAL UNITES WORLD LEADERS IN 3D BIOPRINTING LIVER TISSUE ENGINEERING LIVER AND STEM CELL BIOLOGY 16 TO 22 AND LIVER HEALTH DISPARITIES WITH TWO OF THE WORLDS HIGHEST VOLUME LIVER TRANSPLANT CENTERS. TOGETHER WE WILL SOLVE CRITICAL BARRIERS IN BIOPRINTING AND HUMAN CELL SOURCING TO BUILD 3D PRINTED LIVER THAT WILL OBVIATE THE NEED FOR SYSTEMIC IMMUNOSUPPRESSION AND REPLACE ORGAN TRANSPLANTATION WITH A TRUE CURE FOR LIVER DISEASE NOT JUST FOR SOME BUT FOR ALL PATIENTS.

Carnegie Mellon University

SIGNIFICANT HEALTH IMPACT FOR THE FUTUREOF ORGAN TRANSPLANTATION AND PAVE THE WAY FOR THE NECESSARY NEXT STEPS IN SCALING TISSUE AND ORGANENGINEERING.

93.384 - ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)

Interior Business Center (IBC) [DOI]

Allegheny, Pennsylvania United States

County-Wide

D-AQD-FA-25-013